Effects of Oxygen on Nicotine and Tropane Alkaloid Production in Cultured Roots of Duboisia myoporoides

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概要

• 論文の詳細を見る

• The effects of oxygen on nicotine and tropane alkaloid production in root cultures of Duboisia myoporoides were investigated. Duboisia roots cultured in air produced both nicotine and tropane alkaloids equally. However, when roots were cultured in pure oxygen, the metabolic flux to tropane alkaloids increased, and that to nicotine alkaloids decreased. Intermediate product analysis by GC-MS showed an increase in tropine, but decreases in acetyl derivatives of tropane alkaloids and tropine esters with low-class fatty acids. Furthermore, hyoscyamine 6β-hydroxylase (H6H, EC 1.14.11.11, the key enzyme in the pathway from hyosyamine to scopolamine) also increased. These results suggest that pure oxygen contributes to scopolamine production not only by activating the biosynthetic steps for scopolamine, but also by inactivating the biosynthetic steps for nicotine and other tropine derivatives.

• 社団法人日本農芸化学会の論文
• 1994-10-23

著者

• Yamada Y

  The Department Of Mechanical Engineering And Intelligent Systems University Of Electro-communication

• Hara Yukihiko

  Food Research Institute Mitsui Norin Co. Ltd.

• Yamada Yukio

  Fine Chemicals Research Laboratories Kaneka Corporation

• Yamada Yukio

  Mechanical Engineering Laboratory Material Science And Bioengineering Department Aist

• Hara Y

  Hiroshima Univ. Higashi-hiroshima Jpn

• Yamada Y

  Fac. Of Education Utsunomiya Univ.

• YAMADA YASUYUKI

  Faculty of Agriculture, Kyoto University

• Yukimune Yukihito

  Bioscience Laboratory, Mitsui Petrochemical Industries, Ltd.

• Yamagata Hikaru

  Bioscience Laboratory, Mitsui Petrochemical Industries, Ltd.

• Hara Yasuhiro

  Bioscience Laboratory, Mitsui Petrochemical Industries, Ltd.

• Yamagata Hikaru

  Bioscience Laboratory Mitsui Petrochemical Industries Ltd.

• Yukimune Yukihito

  Bioscience Laboratory Mitsui Petrochemical Industries Ltd.

• Yamada Yasuyuki

  Faculty Of Agriculture Kyoto University

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