A Potent Hypotensive Peptide, Novokinin, Induces Relaxation by AT_2- and IP-Receptor-Dependent Mechanism in the Mesenteric Artery from SHRs
スポンサーリンク
概要
- 論文の詳細を見る
In this study, we found that novokinin (Arg-Pro-Leu-Lys-Pro-Trp), a potent hypotensive peptide acting through the AT2 receptor, has vasorelaxing activity in the mesenteric artery isolated from spontaneously hypertensive rats. The vasorelaxing activity was significantly blocked by PD123319, indomethacin, and CAY10441, which are an AT2 receptor antagonist, a cyclooxygenase inhibitor, and an IP receptor antagonist, respectively. NG-nitro-L-arginine methyl ester, an inhibitor of nitric oxide synthase, did not block the vasorelaxing activity. These results suggest that the vasorelaxing activity of novokinin, which contributes to the hypotensive effect, is mainly mediated by prostaglandin I2 (prostacyclin) and the IP receptor downstream of the AT2 receptor.
- 社団法人 日本農芸化学会の論文
- 2008-01-23
著者
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Yamada Yuko
Division of Cardiology, Department of Internal Medicine, National Cardiovascular Center
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YOSHIKAWA Masaaki
Division of Food Bioscience and Biotechnology, Graduate School of Agriculture, Kyoto University
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Yamada Y
Doshisha Women's Coll. Liberal Arts Kyoto Jpn
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Yamada Y
The Department Of Mechanical Engineering And Intelligent Systems University Of Electro-communication
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Yamada Yuko
Division Of Cardiology Department Of Internal Medicine National Cardiovascular Center
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Yamauchi Daiki
Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University
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Yokoo Megumi
Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University
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OHINATA Kousaku
Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University
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USUI Hachiro
Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University
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Usui H
Kyoto Univ. Kyoto Jpn
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Yamada Yukio
Fine Chemicals Research Laboratories Kaneka Corporation
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Yamada Yasuyuki
Graduate School Of Biological Science Nara Institute Of Science And Technoiogy
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YOSHIKAWA Masaaki
Graduate School of Agriculture, Kyoto University
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Yamada Yukio
Mechanical Engineering Laboratory Material Science And Bioengineering Department Aist
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Yamada Y
Fac. Of Education Utsunomiya Univ.
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Usui Hachiro
Division Of Food Bioscience And Biotechnology Graduate School Of Agriculture Kyoto University
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OHINATA Kousaku
Graduate School of Agriculture, Kyoto University
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Yoshikawa Masaaki
Kyoto Univ. Kyoto Jpn
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Ohinata Kousaku
Kyoto Univ. Kyoto Jpn
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Yokoo Megumi
Division Of Food Science And Biotechnology Graduate School Of Agriculture Kyoto University
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Yamauchi Daiki
Division Of Food Science And Biotechnology Graduate School Of Agriculture Kyoto University
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Yamada Yuko
Kyoto Univ. Kyoto Jpn
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Yoshikawa Masaaki
Division Of Food Bioscience And Biotechnology Graduate School Of Agriculture Kyoto University
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Yoshikawa M
Graduate School Of Agriculture Kyoto University
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Ohinata Kousaku
Division Of Food Science And Biotechnology Graduate School Of Agriculture Kyoto University
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Yamaguchi Yuko
Laboratory For Molecular Functions Of Food Division Of Food Science And Biotechnology Graduate Schoo
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Yamada Yuko
Division Of Arrhythmia And Electrophysiology Department Of Cardiovascular Medicine National Cerebral And Cardiovascular Center
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