Characterization of β-Lactotensin, a Bioactive Peptide Derived from Bovine β-Lactoglobulin, as a Neurotensin Agonist(Food & Nutrition Science)

概要

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β-Lactotensin (β-LT : His-Ile-Arg-Leu) is an ileumcontracting peptide derived from residues No. 146-149 of bovine β-lactoglobulin. The ileum-contracting activity of β-LT was blocked by the NT_1 antagonist SR48692. β-LT was selective for the neurotensin NT_2 receptor while neurotensin was selective for the NT_1 receptor. β-LT is the first natural ligand showing selectivity for the NT_2 receptor. β-LT showed hypertensive activity after intravenous administration at a dose of 30 mg/kg in conscious rats, while neurotensin showed hypotensive activity. The hypertensive activity of β-LT was blocked by levocabastine (1 mg/kg, i. v.), an NT_2 antagonist. SR48692, which blocked the hypotensive activity of neurotensin, had no effect on the hypertensive activity of β-LT. These results suggest that the hypertensive activity of β-LT is mediated by the NT_2 receptor. It was concluded that the NT_1 and NT_2 receptors mediate the opposite effect on blood pressure.
社団法人日本農芸化学会の論文
2003-04-23