Anti-Alopecia Effect of Gly-Leu-Phe, an Immunostimulating Peptide Derived from α-Lactalbumin
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概要
- 論文の詳細を見る
Gly-Leu-Phe (GLF), an immunostimulating peptide derived from α-lactalbumin, prevented alopecia induced by an anticancer agent etoposide in a neonatal rat model after intraperitoneal injection at a dose of 100 mg/kg for 4 d or oral administration at a dose of 300 mg/kg for 6 d. By microscopic analysis of skin sections, GLF proved to inhibit etoposide-induced loss of hair, thickening of the epidermis, and thinning of the adipocyte layer. The anti-alopecia effect of GLF was inhibited by pyrilamine, a histamine H1 receptor antagonist, suggesting that the anti-alopecia effect is mediated by histamine release.
- 社団法人 日本農芸化学会の論文
著者
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YOSHIKAWA Masaaki
Division of Food Bioscience and Biotechnology, Graduate School of Agriculture, Kyoto University
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TSURUKI Takahiro
Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University
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Tsuruki Takahiro
Division Of Food Science And Biotechnology Graduate School Of Agriculture Kyoto University
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Yoshikawa Masaaki
Division Of Food Bioscience And Biotechnology Graduate School Of Agriculture Kyoto University
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