Design of Soymetide-4 Derivatives to Potentiate the Anti-alopecia Effect
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概要
- 論文の詳細を見る
Previously, we found that soymetide-4 (MITL), an N-formyl-methionyl-leucyl-phenylalanine (fMLP) agonist peptide derived from soybean β-conglycinin α′ subunit, stimulated phagocytosis of human polymorphonuclear leukocytes, and inhibited alopecia induced by etoposide, an anticancer drug, in neonatal rats after oral administration. We found that the fMLP receptor affinity and phagocytosis-stimulating activity of soymetide-4 was potentiated by replacement of Thr3 with hydrophobic residues. Among the derivatives synthesized, [Trp]3-soymetide-4 (MIWL) was the most potent, stronger by 180 and 130 times than soymetide-4 in receptor affinity and phagocytosis-stimulating activity, respectively. The anti-alopecia effect of [Trp]3-soymetide-4 was about 3 times larger than that of soymetide-4 after oral administration.
- 社団法人 日本農芸化学会の論文
- 2004-05-23
著者
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Yoshikawa Masaaki
Division Of Food Science And Biotechnology Graduate School Of Agriculture Kyoto University
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TSURUKI Takahiro
Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University
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Tsuruki Takahiro
京都大学 農学研究科食品生物科学
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Tsuruki Takahiro
Division Of Food Science And Biotechnology Graduate School Of Agriculture Kyoto University
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Yoshikawa Masaaki
Division Of Food Bioscience And Biotechnology Graduate School Of Agriculture Kyoto University
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