Design of a Highly Potent Anti-hypertensive Peptide Based on Ovokinin(2-7)(Biochemistry & Molecular Biology)
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概要
- 論文の詳細を見る
Ovokinin(2-7) (RADHPF), an orally active anti-hypertensive peptide derived from ovalbumin, lowers blood pressure in SHRs at a dose of 10 mg/kg. Attempts were made to potentiate its anti-hypertensive activity by replacing the amino acid residues in [Pro^2, Phe^3]-ovokinin(2-7), which was previously reported to have 33-fold stronger activity than ovokinin(2-7). The anti-hypertensive activity of [Pro^2, Phe^3]-ovokinin(2-7) was improved by replacement of the C-terminal Phe residue with Trp. Then, the best amino acid residues at other positions for the anti-hypertensive effect were selected. RPLKPW, the most potent derivative obtained, showed significant anti-hypertensive activities at a dose of 0.1 mg/kg after oral administration in spontaneously hypertensive rats (SHRs). Thus, RPLKPW showed 100-fold more potent anti-hypertensive activity than ovokinin(2-7).
- 社団法人日本農芸化学会の論文
- 2002-06-23
著者
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Yamada Yuko
Division of Cardiology, Department of Internal Medicine, National Cardiovascular Center
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YOSHIKAWA Masaaki
Division of Food Bioscience and Biotechnology, Graduate School of Agriculture, Kyoto University
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Yamada Y
Doshisha Women's Coll. Liberal Arts Kyoto Jpn
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Yamada Y
The Department Of Mechanical Engineering And Intelligent Systems University Of Electro-communication
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Yamada Yuko
Division Of Cardiology Department Of Internal Medicine National Cardiovascular Center
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USUI Hachiro
Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University
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MATOBA Nobuyuki
Division of Food Bioscience and Biotechnology, Graduate School of Agriculture, Kyoto University
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USUI Hadhiro
Division of Food Bioscience and Biotechnology, Graduate School of Agriculture, Kyoto University
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ONISHI Kunihiko
Division of Food Bioscience and Biotechnology, Graduate School of Agriculture, Kyoto University
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Usui H
Kyoto Univ. Kyoto Jpn
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Onishi Kunihiko
Division Of Food Bioscience And Biotechnology Graduate School Of Agriculture Kyoto University
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Yamada Yukio
Fine Chemicals Research Laboratories Kaneka Corporation
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Yamada Yasuyuki
Graduate School Of Biological Science Nara Institute Of Science And Technoiogy
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YOSHIKAWA Masaaki
Graduate School of Agriculture, Kyoto University
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Yamada Yukio
Mechanical Engineering Laboratory Material Science And Bioengineering Department Aist
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Yamada Y
Fac. Of Education Utsunomiya Univ.
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Usui Hachiro
Division Of Food Bioscience And Biotechnology Graduate School Of Agriculture Kyoto University
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Yamada Y
Faculty Of Education Utsunomiya University
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Yoshikawa Masaaki
Kyoto Univ. Kyoto Jpn
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Matoba Nobuyuki
Division Of Food Bioscience And Biotechnology Graduate School Of Agriculture Kyoto University
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Yamada Yuko
Kyoto Univ. Kyoto Jpn
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Yoshikawa Masaaki
Division Of Food Bioscience And Biotechnology Graduate School Of Agriculture Kyoto University
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Yoshikawa M
Graduate School Of Agriculture Kyoto University
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Yamaguchi Yuko
Laboratory For Molecular Functions Of Food Division Of Food Science And Biotechnology Graduate Schoo
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Yamada Yuko
Division Of Arrhythmia And Electrophysiology Department Of Cardiovascular Medicine National Cerebral And Cardiovascular Center
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