Enterostatin (VPDPR) and Its Peptide Fragment DPR Reduce Serum Cholesterol Levels after Oral Administration in Mice(Food & Nutrition Science)
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概要
- 論文の詳細を見る
We found that enterostatin (VPDPR), an anorexigenic peptide for a high-fat diet, significantly reduces serum cholesterol levels after oral administration of 100 mg/kg for 3 days in mice fed a high cholesterol-cholic acid diet. DPR, a peptide fragment of VPDPR, also had hypocholesterolemic activity at a dose of 50 mg/kg. Food intake was not suppressed under these dietary conditions. Fecal excretion of cholesterol and bile acids was increased significantly by both VPDPR and DPR. Interestingly, DPR induced hypocholesterolemic effects just two hours after a single oral administration at a dose of 100 mg/kg.
- 社団法人日本農芸化学会の論文
- 2003-07-23
著者
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YOSHIKAWA Masaaki
Division of Food Bioscience and Biotechnology, Graduate School of Agriculture, Kyoto University
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YOSHIKAWA Masaaki
Graduate School of Agriculture, Kyoto University
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TAKENAKA Yasuyuki
Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University
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Takenaka Y
Fermentation And Biotechnology Laboratories Ajinomoto Co. Inc.
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Takenaka Yasuyuki
Division Of Food Science And Biotechnology Graduate School Of Agriculture Kyoto University
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NAKAMURA Futoshi
Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University
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YAMAMOTO Taichi
Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University
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Yoshikawa Masaaki
Kyoto Univ. Kyoto Jpn
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Yamamoto Taichi
Division Of Food Science And Biotechnology Graduate School Of Agriculture Kyoto University:(present
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Takenaka Y
Division Of Food Science And Biotechnology Graduate School Of Agriculture Kyoto University
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Nakamura Futoshi
Division Of Food Science And Biotechnology Graduate School Of Agriculture Kyoto University:(present
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Yoshikawa Masaaki
Division Of Food Bioscience And Biotechnology Graduate School Of Agriculture Kyoto University
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Yoshikawa M
Graduate School Of Agriculture Kyoto University
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Takenaka Yasuyuki
Kobe Shoin Woman's University
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