Soymorphins, Novel μ Opioid Peptides Derived from Soy β-Conglycinin β-Subunit, Have Anxiolytic Activities

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概要

• 論文の詳細を見る

• Based on the amino acid sequence YPFV found in the soy β-conglycinin β-subunit, which is common to an opioid peptide human β-casomorphin-4, peptides YPFVV, YPFVVN, and YPFVVNA were synthesized according to their primary structure. On guinea pig ileum (GPI) assay, they showed opioid activity (IC50 = 6.0, 9.2 and 13 μM respectively) more potent than human β-casomorphins, and were named soymorphins-5, -6, and -7, respectively. Their opioid activities on mouse vas deferens (MVD) assay were less potent than on GPI assay, suggesting that they are selective for the μ opioid receptor. Human β-casomorphin-4 and soymorphin-5 were released from the soy 7S fraction (β-conglycinin) by the action of gastrointestinal proteases. Soymorphins-5, -6, and -7 had anxiolytic activities after oral administration at doses of 10–30 mg/kg in the elevated plus-maze test in mice.

• 社団法人 日本農芸化学会の論文
• 2007-10-23

著者

• YOSHIKAWA Masaaki

  Division of Food Bioscience and Biotechnology, Graduate School of Agriculture, Kyoto University

• OHINATA Kousaku

  Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University

• OHINATA Kousaku

  Graduate School of Agriculture, Kyoto University

• Yoshikawa Masaaki

  Kyoto Univ. Kyoto Jpn

• Ohinata Kousaku

  Kyoto Univ. Kyoto Jpn

• AGUI Shun

  Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University

• Agui Shun

  Division Of Food Science And Biotechnology Graduate School Of Agriculture Kyoto University

• Yoshikawa Masaaki

  Division Of Food Bioscience And Biotechnology Graduate School Of Agriculture Kyoto University

• Ohinata Kousaku

  Division Of Food Science And Biotechnology Graduate School Of Agriculture Kyoto University

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