Mechanism of the Protective Effect of Intraperitoneally Administered Agonists for Formyl Peptide Receptors against Chemotherapy-Induced Alopecia

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概要

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• Previously, we found that an intraperitoneally administered chemotactic peptide, N-formyl-Met-Leu-Phe (fMLP), and MMK-1, a selective agonist of formyl peptide receptor-like 1 (FPRL1) receptor, the low affinity subtype of the fMLP receptor, prevented the alopecia in neonatal rats induced by the anticancer agent etoposide. The anti-alopecia effect of fMLP was not inhibited at all by Boc-FLFLF, a selective antagonist of formylpeptide receptor (FPR), which is the high affinity subtype of the fMLP receptor, but it was partly inhibited by Trp-Arg-Trp-Trp-Trp-Trp-NH2 (WRW4), an antagonist of FPRL1 receptor. On the other hand, the anti-alopecia effect of MMK-1 was completely abolished by WRW4. The anti-alopecia effects of fMLP and MMK-1 were also inhibited by Lys-D-Pro-Thr (K(D)PT) and pyrrolidine dithiocarbamate, which are inhibitors of interleukin-1 (IL-1) and nuclear factor-κB (NF-κB) respectively. Hence, we suggest that the anti-alopecia mechanisms of intraperitoneally administered fMLP and MMK-1 include activation of NF-κB via IL-1 release downstream of the FPRL1 receptor homolog in rats.

• 社団法人 日本農芸化学会の論文

著者

• YOSHIKAWA Masaaki

  Division of Food Bioscience and Biotechnology, Graduate School of Agriculture, Kyoto University

• TAKAHATA Kyoya

  Department of Bioresources Chemistry, Faculty of Agriculture, Okayama University

• TSURUKI Takahiro

  Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University

• Takahata Kyoya

  Department Of Food Science Yamawaki Gakuen Junior College

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