Tumor Chemopreventive Effect of Orally Administered (-)-Epigallocatechin and Its 3-O-Acylated Derivatives on the Two Stage Mouse Skin Carcinogenesis Induced by Peroxynitrite and 12-O-Tetradecanoylphorbol-13-acetate
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概要
- 論文の詳細を見る
(-)-Epigallocatechin (EGC) and its acylated derivatives, 3-O-octanoyl-(-)-EGC and 3-O-[(RS)-2-methyloctanoyl]-(-)-EGC, were examined by oral administration for the suppression effect on the two stage mouse skin carcinogenesis which were induced by NO as an initiator and 12-O-tetradecanoylphorbol-13-acetate (TPA) as a promoter. Although there was no significant difference in the effect among these catechins, they all suppressed papilloma formation compared with the control at the following overwhelming rates: 90.1% for (-)-EGC, 85.2% for 3-O-octanoyl-(-)-EGC and 8 1.5 % for 3-O-[(R.S)-2-methyloctanoyl]-(-)-EGC. It was thus deduced that (-)-EGC can be an orally active candidate for tumor chemoprevention.
- 日本生薬学会の論文
- 2005-02-20
著者
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Hara Y
Mitsui Norin Co. Ltd. Shizuoka
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KUMAGAI Ayako
Department of Biotechnology, Faculty of Engineering, Kansai University
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Nishino H
Department Of Biochemistry Kyoto Prefectural University Of Medicine
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Nishino H
Department Of Biochemistry And Molecular Biology Kyoto Prefectural University Of Medicine
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西村 弘行
National Cancer Center Research Institute
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Nishino Hoyoku
Department Of Biochemistry And Molecular Biology Graduate School Of Medical Science Kyoto Prefectura
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Nagaoka Yasuo
Department Of Biotechnology Faculty Of Engineering Kansai Univeristy
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Uesato S
Department Of Life Science And Biotechnology Faculty Of Chemistry Material And Bioengineering Kansai
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Uesato Shinichi
Department Of Biotechnology Faculty Of Engineering Kansai Univeristy
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Tokuda H
Department Of Biochemistry Kyoto Prefectural University Of Medicine
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Tokuda Harukuni
Department Of Biochemistry And Molecular Biology Kyoto Prefectural University Of Medicine
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Tokuda Harukuni
Department Of Microbiology Faculty Of Medicine Kyoto University
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Tokuda Harukuni
Department Of Biochemistry Kyoto Prefectural University Of Medicine
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Nagaoka Y
Kansai Univ. Osaka Jpn
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Kumagai Ayako
Department Of Life Science And Biotechnology Faculty Of Chemistry Material And Bioengineering Kansai
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Uesato S
Dep. Of Life Sci. And Biotechnology Fac. Of Chemistry Materials And Engineering Kansai Univ.
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Nagaoka Yasuo
Department Of Biotechnology Faculty Of Engineering Kansai University:high Technology Research Center
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Hara Yukihiko
Food Research Institute Mitsui Norin Co.
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Nagaoka Yasuo
Department Of Life Science And Biotechnology Faculty Of Chemistry Material And Bioengineering Kansai
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Nagaoka Yasuo
Fac. Of Chemistry Materials And Bioengineering Kansai Univ.
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