3-Epicabraleahydroxylactone and Other Triterpenoids from Camellia Oil and Their Inhibitory Effects on Epstein-Barr Virus Activation

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概要

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• The structure of a triterpenoid isolated from the nonsaponifiable lipid (NSL) of the seed oil of the camellia (Camellia japonica L.; Theaceae) was established to be (20S)-3β-hydroxy-25,26,27-trisnordammaran-24,20-olide (1; 3-epicabraleahydroxylactone) on the basis of spectroscopic and chemical methods. Six other triterpenoids isolated from the NSL were identified as 3-epicabraleadiol (2), ocotillol II (3), ocotillol I (4), dammarenediol II (5), (20R)-taraxastane-3β,20-diol (6), and lupane-3β,20-diol (7). Upon evaluation of the seven triterpenoids (1-7) with respect to their inhibitory effects on the induction of Epstein-Barr virus early antigen (EBV-EA) by 12-O-tetradecanoylphorbol-13-acetate (TPA) in Raji cells, three compounds (5-7) showed potent inhibitory effects against EBV-EA induction (IC_<50> values of 277-420 mol ratio/32 pmol TPA).

• 公益社団法人日本薬学会の論文
• 2004-01-01

著者

• 小池 一男

  東邦大・薬

• Akihisa Toshihiro

  College of Science and Technology, Nihon University

• TOKUDA Harukuni

  Department of Molecular Biochemistry, Kyoto Prefectural University of Medicine

• Suzuki T

  Department Of Biochemistry University Of Shizuoka School Of Pharmaceutical Sciences:core Research Fo

• Koike Kazuo

  Toho University School Of Pharmaceutical Sciences

• Nishino H

  Toho University School Of Pharmaceutical Sciences

• Nishino H

  Department Of Biochemistry And Molecular Biology Kyoto Prefectural University Of Medicine

• Suzuki T

  Department Of Pharmaceutics College Of Pharmacy Nihon University

• Suzuki Takashi

  School Of Pharmacy Nihon Univ.

• 二階堂 保

  Faculty of Pharmaceutical Sciences, Toho University

• TOKUDA Harukuni

  Kyoto Prefectural University of Medicine

• UKIYA Motohiko

  College of Science and Technology, Nihon University

• Akihisa T

  College Of Pharmacy Nihon University

• Akihisa Toshihiro

  日本大学 理工学部

• Akihisa Toshihiro

  College Of Science And Technology Nihon University

• Nishino Hoyoku

  Toho University School Of Pharmaceutical Sciences

• Tokuda Harukuni

  Dep. Of Complementary And Alternative Medicine Clinical R&d Graduate School Of Medical Sci. Kana

• Tokuda Harukuni

  Department Of Biochemistry And Molecular Biology Kyoto Prefectural University Of Medicine

• Enjo Fumio

  Department Of Biochemistry Kyoto Prefectural University Of Medicine

• Ukiya Motohiko

  College Of Science And Technology Nihon University

• KUMAKI Kunio

  The Yamagata Prefectural Institute of Public Health

• Suzuki Takashi

  Department Of Biochemistry University Of Shizuoka School Of Pharmaceutical Sciences:core Research Fo

• 二階堂 保

  Faculty Of Pharmaceutical Sciences Toho University

• SUZUKI Toshie

  Oshima Tsubaki Co.

• NIKAIDO Tamotsu

  Toho University School of Pharmaceutical Sciences

• Koike Kazuo

  Toho Univ. Chiba Jpn

• Takase S

  College Of Science And Technology (funabashi Campus) Nihon University

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