Melanogenesis Inhibitory and Free Radical Scavenging Activities of Diarylheptanoids and Other Phenolic Compounds from the Bark of Acer nikoense(Pharmacognosy)

スポンサーリンク

概要

• 論文の詳細を見る

• Melanogenesis inhibitory and free radical scavenging activities of nine cyclic (1-9) and one acyclic diarylheptanoids (10), and two phenolic compounds, (+)-rhododendrol (11) and (+)-catechin (12), isolated from the ethyl acetate-soluble fraction of the MeOH extract of the bark of Acer nikoense MAXIM. (Aceraceae) were examined. Upon evaluation of compounds 1-12 on the melanogenesis in the B16 melanoma cells, two compounds, 2 and 8, exhibited marked inhibitory activity with 55.6% and 46.8% reduction, respectively, of melanin content at 25μg/ml without inhibition of cell proliferation. In addition, upon an evaluation of eleven compounds, 1-7 and 9-12 against the scavenging activities of free radicals (against the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical), compound 12 (IC_<50> 9.0μM) followed by compounds 1, 3, 4, and 6 (IC_<50> 40.2-44.0μM) showed potent scavenging activities.

• 公益社団法人日本薬学会の論文
• 2006-09-01

著者

• Akihisa Toshihiro

  College of Science and Technology, Nihon University

• Banno Norihiro

  Ichimaru Pharcos Company Ltd.

• Kimura Y

  Coll. Of Pharmacy Nihon Univ.

• AKAZAWA Hiroyuki

  College of Science and Technology, Nihon University

• TAGUCHI Yosuke

  College of Science and Technology, Nihon University

• YASUKAWA Ken

  College of Pharmacy, Nihon University

• Banno Norihiro

  Ichimaru Pharcos Co. Ltd.

• Yasukawa Ken

  Coll. Of Pharmacy Nihon Univ.

• Yasukawa Ken

  College Of Pharmacy Nihon University

• Akihisa T

  College Of Pharmacy Nihon University

• Akihisa Toshihiro

  日本大学 理工学部

• Akihisa Toshihiro

  College Of Science And Technology Nihon University

• YONEIMA Risa

  College of Science and Technology, Nihon University

• Yoneima Risa

  College Of Science And Technology Nihon University

• Taguchi Yosuke

  College Of Science And Technology Nihon University

関連論文

• 天然物由来抗酸化性化合物のマスト細胞活性化抑制の作用機序
• Albanol A from the Root Bark of Morus alba L. Induces Apoptotic Cell Death in HL60 Human Leukemia Cell Line
• 24OP1-4 神経芽腫に対するアシタバ由来成分xanthoangelolの酸化ストレスを介するアポトーシス誘導効果(ポスター NBL(基礎),第22回日本小児がん学会 第48回日本小児血液学会 第4回日本小児がん看護研究会 同時期開催)
• OP38-4 神経芽腫細胞培養株に対するレイシ由来トリテルペンの分化誘導効果について(ポスター 神経芽腫9,第21回日本小児がん学会 第47回日本小児血液学会 同時期開催)
• Inhibitory Effect of Some Oxygenated Stigmastane-Type Sterols on 12-O-Tetradecanoylphorbol-13-acetate-Induced Inflammation in Mice
• Structures of Five Hydroxylated Sterols from the Seeds of Trichosanthes kirilowii MAXIM.
• Five D : C-Friedo-Oleanane Triterpenes from the Seeds of Trichosanthes kirilowii MAXIM. and Their Anti-inflammatory Effects
• Inhibitory Effect of Karounidiol on 12-O-Tetradecanoylphorbol-13-acetate-Induced Tumor Promotion
• クスノキ科植物のステロール成分
• EVS1-1 IgEによる未成熟ヒトマスト細胞のFcεRIを介する脱顆粒能の獲得とヒト型抗IgE抗体による抑制(EVS1 重症喘息の治療戦略〜IgEをターゲットとした治療,イブニングシンポジウム,第60回日本アレルギー学会秋季学術大会)
• The Melanogenesis-Inhibitory, Anti-Inflammatory, and Chemopreventive Effects of Limonoids in n-Hexane Extract of Azadirachta indica A. Juss. (Neem) Seeds
• 4-Hydroxyderricin from Angelica keiskei Roots Induces Caspase-dependent Apoptotic Cell Death in HL60 Human Leukemia Cells
• 168 天然物由来抗酸化性化合物によるマスト細胞活性化の修飾
• Cytotoxic activity of Perilla frutescens var. japonica leaf extract is due to high concentrations of oleanolic and ursolic acids
• Proteomic Analysis of Apoptosis Induced by Xanthoangelol, a Major Constituent of Angelica keiskei, in Neuroblastoma(Pharmacology)
• Isobavachalcone, a Chalcone Constituent of Angelica keiskei, Induces Apoptosis in Neuroblastoma(Pharmacology)
• Cancer Chemopreventive Effects and Cytotoxic Activities of the Triterpene Acids from the Resin of Boswellia carteri(Pharmacognosy)
• Xanthoangelol, a Major Chalcone Constituent of Angelica keiskei, Induces Apoptosis in Neuroblastoma and Leukemia Cells(Pharmacology)
• Triterpene Alcohols and Sterols from the Fern Gleichenia japonica SPR.
• Inhibitory effect of the rhizomes of Alpinia officinarum on TPA-induced inflammation and tumor promotion in two-stage carcinogenesis in mouse skin
• 24OP1-11 神経芽腫細胞培養株に対するアシタバ由来成分isobavachalconeの選択的アポトーシス誘導効果について(ポスター NBL(基礎),第22回日本小児がん学会 第48回日本小児血液学会 第4回日本小児がん看護研究会 同時期開催)
• 6S, 8R-Stereochemistry of the C_- and C_-Alkane-6,8-diols Isolated from Three Compositae Flowers
• 24OP1-19 神経芽腫細胞に対する乳香由来トリテルペンの抗腫瘍効果(ポスター NBL(基礎),第22回日本小児がん学会 第48回日本小児血液学会 第4回日本小児がん看護研究会 同時期開催)
• Clusia guaviarensisからの新規トリテルペノイド(17α,20R)-Dammara-12,24-dien-3β-ol
• メグスリノキ樹皮およびヤマモモ樹皮由来環状ジアリールヘプタノイドのメラニン産生抑制効果 (特集 最新のメラニン研究と美白剤の開発)
• 天然トリテルペンの抗炎症,抗腫瘍および発がん予防機能 (特集 脂質と脂溶性化合物の健康栄養機能--最近の研究の進歩)
• JAWC 2000 に参加して
• 5-Dehydrokarounidiol [D : C-Friedo-oleana-5,7,9(11)-triene-3α, 29-diol], a Novel Triterpene from Trichosanthes kirilowii MAXIM.
• 7-Oxodihydrokarounidiol [7-Oxo-D : C-friedo-olean-8-ene-3α, 29-diol], a Novel Triterpene from Trichosanthes kirilowii
• Three New Cyclic Diarylheptanoids and Other Phenolic Compounds from the Bark of Myrica rubra and Their Melanogenesis Inhibitory and Radical Scavenging Activities
• Melanogenesis Inhibitory and Free Radical Scavenging Activities of Diarylheptanoids and Other Phenolic Compounds from the Bark of Acer nikoense(Pharmacognosy)
• Anti-inflammatory and Antitumor-Promoting Effects of the Triterpene Acids from the Leaves of Eriobotrya japonica(Pharmacognosy)
• Triterpene Acids from the Leaves of Perilla frutescens and Their Anti-inflammatory and Antitumor-promoting Effects
• 3-O-(E)-p-Coumaroyl Tormentic Acid from Eriobotrya japonica Leaves Induces Caspase-Dependent Apoptotic Cell Death in Human Leukemia Cell Line
• Anti-Inflammatory and Chemopreventive Effects of Triterpene Cinnamates and Acetates from Shea Fat
• Inhibitory Effect of Cycloartenol Ferulate, a Component of Rice Bran, on Tumor Promotion in Two-Stage Carcinogenesis in Mouse Skin
• Triterpene Alcohols from Camellia and Sasanqua Oils and Their Anti-inflammatory Effects
• 4-Epicycloeucalenone and 4-Epicyclomusalenone : Two 3-Oxo-28-norcycloartanes from the Fruit Peel of Musa sapientum L.
• Cyclokirilodiol and Isocyclokirilodiol : Two Novel Cycloartanes from the Seeds of Trichosanthes kirilowii MAXIM.
• Inhibitory Effect of Di- and Trihydroxy Triterpenes from the Flowers of Compositae on 12-O-Tetradecanoylphorbol-13-acetate-Induced Inflammation in Mice
• Helianol [3,4-seco-19(10→9)abeo-8α, 9β, 10α-eupha-4,24-dien-3-ol], a Novel Triterpene Alcohol from the Tabular Flowers of Helianthus annuus L.
• Eight Novel Sterols from the Roots of Bryonia dioica JACQ.
• Inhibitory Effects of Sterols Isolated from Chlorella vulgaris on 12-O-Tetradecanoylphorbol-13-acetate-Induced Inflammation and Tumor Promotion in Mouse Skin
• 3-Epicabraleahydroxylactone and Other Triterpenoids from Camellia Oil and Their Inhibitory Effects on Epstein-Barr Virus Activation
• 天然甘味料の発がん予防効果
• Acerogenin M, a Cyclic Diarylheptanoid, and Other Phenolic Compounds from Acer nikoense and Their Anti-inflammatory and Anti-tumor-Promoting Effects
• Antitubercular Activity and Inhibitory Effect on Epstein-Barr Virus Activation of Sterols and Polyisoprenepolyols from an Edible Mushroom, Hypsizigus marmoreus(Pharmacognosy)
• Antitubercular Activity of Triterpenoids from Asteraceae Flowers(Pharmacognosy)
• Inhibitory effects of falconensins on 12-O-tetradecanoylphorbol-13-acetate-induced inflammatory ear edema in mice
• Triterpene Alcohol and Fatty Acid Composition of Shea Nuts from Seven African Countries
• Melanogenesis Inhibitory Activities of Iridoid-, Hemiterpene-, and Fatty Acid-glycosides from the Fruits of Morinda citrifolia (Noni)
• Melanogenesis Inhibitory, Anti-Inflammatory, and Chemopreventive Effects of Limonoids from the Seeds of Azadirachta indicia A. Juss. (Neem)
• A novel DNA topoisomerase inhibitor : dehydroebriconic acid, one of the lanostane-type triterpene acids from Poria cocos
• Dehydrotrametenonic Acid and Dehydroeburiconic Acid from Poria cocos and Their Inhibitory Effects on Eukaryotic DNA Polymerase α and β
• Astertarone A : A Triterpenoid Ketone Isolated from the Roots of Aster tataricus L.
• Inhibitory Effect of Stevioside on Tumor Promotion by 12-O-Tetradecanoylphorbot-13-acetate in Two-Stage Carcinogenesis in Mouse Skin
• Astertarone B, a Hydroxy-Triterpenoid Ketone from the Roots of Aster tataricus L.
• Cycloarta-16,24-dien-3β-ol : Revised Structure of Cimicifugenol, a Cycloartane Triterpenoid
• Antiviral activities of diarylheptanoids against influenza virus in vitro
• Triacylglycerol and Triterpene Ester Composition of Shea Nuts from Seven African Countries
• Inhibitory effect of the flowers of artichoke (Cynara cardunculus) on TPA-induced inflammation and tumor promotion in two-stage carcinogenesis in mouse skin
• Triacylglycerol and triterpene ester composition of shea nuts from seven African countries
• NMRスペクトル法によるウコン成分クルクミンの構造解析(講座:測定の考え方と実際の装置)
• Bioactive Phenolic Compounds from Catharanthus roseus and Vinca minor
• Cytotoxic and Apoptosis-Inducing Activities of 12-O-Acetylazedarachin B from the Fruits of Melia azedarach in Human Cancer Cell Lines

もっと見る 閉じる

スポンサーリンク