Inhibitory Effect of Karounidiol on 12-O-Tetradecanoylphorbol-13-acetate-Induced Tumor Promotion
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概要
- 論文の詳細を見る
Karounidiol [D : C-Friedo-oleana-7,9 (11)-diene-3α, 29-diol] and 7-oxodihydrokarounidiol [7-oxo-D : C-friedo-olean-8-ene-3α, 29-diol], isolated from the seeds of Trichosanthes kirilowii, were examined for the effect on 12-O-tetradecanoylphorbol-13-acetate (TPA, 1μg/ear)-induced inflammation, following application of this tumorpromoting agent, to the ears of mice. Both compounds inhibited the inflammatory activity induced by TPA and the 50% inhibitory dose for TPA-induced inflammation was 0.3 and 0.4 mg/ear, respectively. Furthermore, at 2 μmol/mouse, karounidiol markedly suppressed the promoting effect of TPA (1 μg/mouse) on skin tumor formation in mice following initiation with 7,12-dimethylbenz [a] anthracene (50 μg/mouse).
- 社団法人日本薬学会の論文
- 1994-03-15
著者
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安川 憲
日本大学薬学部生薬学研究室
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安川 憲
College of Pharmacy, Nihon University
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滝戸 道夫
College of Pharmacy, Nihon University
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秋久 俊博
College of Science and Technology, Nihon University
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田村 利武
College of Science and Technology, Nihon University
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Kimura Y
Coll. Of Pharmacy Nihon Univ.
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滝戸 道夫
College Of Pharmacy Nihon University
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滝戸 道夫
日本大学薬学部生薬学研究室
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田村 利武
日本大学理工学部物質応用化学科
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田村 利武
College Of Science And Technology Nihon University
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秋久 俊博
日本大学理工学部物質応用化学科
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Yasukawa Ken
Coll. Of Pharmacy Nihon Univ.
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Akihisa T
College Of Pharmacy Nihon University
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秋久 俊博
日本大学理工学部
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