Inhibitory Effect of Stevioside on Tumor Promotion by 12-O-Tetradecanoylphorbot-13-acetate in Two-Stage Carcinogenesis in Mouse Skin
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概要
- 論文の詳細を見る
Four steviol (ent-kaurene-type diterpenoid) glycosides, stevioside, rebaudiosides A and C, and dulcoside A, have been isolated from Stevia rebaudiana BERTONI. These compounds showed strong inhibitory activity against 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation in mice. The 50% inhibitory dose of these compounds for TPA-induced inflammation was 54.1-291.6μg/ear. Furthermore, at 1.0 and 0.1 mg/mouse of stevioside mixture, the mixture of these compounds markedly inhibited the promoting effect of TPA (1μg/mouse) on skin tumor formation initiated with 7,12-dimethylbenz[a]anthracene (50μg/mouse).
- 公益社団法人日本薬学会の論文
- 2002-11-01
著者
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KITANAKA Susumu
College of Pharmacy, Nihon University
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SEO Shujiro
Tokiwa Phytochemical Co., Ltd.
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Seo S
Tokiwa Phytochemical Co. Chiba Jpn
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Seo Shujiro
Tokiwa Phytochemical Co.
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Kimura Y
Coll. Of Pharmacy Nihon Univ.
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YASUKAWA Ken
College of Pharmacy, Nihon University
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Kitanaka Susumu
College Of Pharmacy Nihon University
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Yasukawa Ken
College Of Pharmacy Nihon University
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