Biotransformation of estragole by the plant cultured cells of Caragana chamlagu

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概要

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• Estragole (EG) is biosynthesized in herbs including anise, basil, bay, tarragon, fennel and marjoram, and is thought to be a useful biomass for the food and health industries. Moreover, the metabolites from estragole are useful intermediates in organic synthetic chemistry. However, estragole has been transformed only by chemical methods, and no biocatalysts have been reported. In this paper, we report the biotransformation of estragole using the plant cells of Caragana chamlagu gave 4-methoxycinnamaldehyde (MCAL), 4-methoxycinnamyl alcohol (MCA) and 4-methoxybenzaldehyde (MBAL). In addition, we propose a reaction mechanism in the biotransformation of estragole using Caragana chamlagu. Since estragole generates malignant liver tumors in the rat, it is necessary to reduce exposure. The present study reveals the transformation of harmful estragole. Furthermore, we succeeded in biotransforming estragole as biomass using plant cells into useful compounds.

• 日本植物細胞分子生物学会の論文
• 2011-06-25

著者

• KITANAKA Susumu

  College of Pharmacy, Nihon University

• Kitanaka Susumu

  College Of Pharmacy Nihon University

• Murakami Masahiko

  Department Of Chemical Engineering Tohoku University

• Takido Toshio

  Department Of Materials And Applied Chemistry College Of Science And Technology Nihon University

• Satoh Hiroaki

  Department Of Internal Medicine Mito Medical Center University Of Tsukuba

• Itoh Ken-ichi

  Department Of Electrical And Computer Engineering Faculty Of Technology Kanazawa University

• Nakamura Kaoru

  Graduate School Of Human Development And Environment 'science Shop' Kobe University

• Sakamaki Hiroshi

  Department of Liberal Arts and Science, College of Science and Technology, Nihon University

• Aoyama Tadashi

  Department Of Materials And Applied Chemistry College Of Science And Technology Nihon University

• Murakami Masahiko

  Department Of Liberal Arts And Science College Of Science And Technology Nihon University

• Sakamaki Hiroshi

  Department Of Liberal Arts And Science College Of Science And Technology Nihon University

• Satoh Hiroaki

  Department Of Materials And Applied Chemistry College Of Science And Technology Nihon University

• Itoh Ken-ichi

  Department Of Liberal Arts And Science College Of Science And Technology Nihon University

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