Anti-allergic Agents from Natural Sources (4) : Anti-allergic Activity of New Phloroglucinol Derivatives from Mallotus philippensis (Euphorbiaceae)

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概要

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• Two new phioroglucinol derivatives, mallotophilippen A (1) and B (2) were isolated from the fruits of Mallotus philippensis. These compounds were identified, using chemical and spectral data, as 1-[5,7-dihydroxy-2,2-di-methyl-6-(2,4,6-trihydroxy-3-isobutyryl-5-methyl-benzyl)-2H-chromen-8-yl]-2-methyl-butan-1-one and 1-[6-(3-Acetyl-2,4,6-trihydroxy-5-methyl-benzyl)-5,7-dihydroxy-2,2-dimethyl-2H-chromen-8-yl]-2-methyl-butan-1-one, respectively. They inhibited nitric oxide (NO) production and inducible NO synthase (iNOS) gene expression by a murine macrophage-like cell line (RAW 264.7), which was activated by lipopolysaccharide (LPS) and recombinant mouse interferon- γ(IFN-γ). Furthermore, they inhibited histamine release from rat peritoneal mast cells induced by Compound 48/80. These results suggest that the novel phloroglucinol derivatives have anti-inflammatory effects.

• 公益社団法人日本薬学会の論文
• 2002-12-01

著者

• KITANAKA Susumu

  College of Pharmacy, Nihon University

• WU Jin-Bin

  Institute of Pharmaceutical Chemistry, China Medical College

• Wu J‐b

  Institute Of Pharmaceutical Chemistry China Medicinal University

• Wu Jin-bin

  Institute Of Pharmaceutical Chemistry China Medical College

• Kitanaka Susumu

  Res. Unit Of Pharmacognosy School Of Pharmacy Nihon Univ.

• Kitanaka Susumu

  College Of Pharmacy Nihon University

• DAIKONYA Akihiro

  College of Pharmacy, Nihon University

• KATSUKI Shigeki

  Tanegashima Experimental Station for Medicinal Plants, National Institute of Health Sciences

• Daikonya Akihiro

  Res. Unit Of Pharmacognosy School Of Pharmacy Nihon Univ.

• Daikonya Akihiro

  College Of Pharmacy Nihon University

• Katsuki Shigeki

  Tanegashima Division Research Center For Medicinal Plant Resources National Institute Of Biomedical

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