Stilbene Derivatives from Pholidota chinensis and Their Anti-inflammatory Activity
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概要
- 論文の詳細を見る
Ethyl acetate extract of Pholidota chinensis L. showed strong NO production inhibitory activity in murine macrophage-like cell line, RAW 264.7, which was activated by a lipopolysaccharide (LPS) and interferon-γ (IFN-γ). Fractionation of the active extract led to the isolation of two new stilbene derivatives, 2,3'-dihydroxy-5-methoxy-3,4-methylenedioxydihydrostilbene (Pholidotol A) and 2-hydroxy-5-methoxy-3,4,3',4'-dimethylene-dioxydihydrostilbene (Pholidotol B) together with six known stilbene derivatives. Pholidotols A both B and inhibited Nitric oxide (NO) production with an IC_<50> value at 24.3 and 17.1μm, respectively.
- 2006-08-01
著者
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Matsuzaki Keiichi
Department Of Applied Physics Faculty Of Engineering University Of Miyazaki
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Kitanaka Susumu
Res. Unit Of Pharmacognosy School Of Pharmacy Nihon Univ.
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Kitanaka Susumu
Department Of Pharmacognosy College Of Pharmacy Nihon University
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Wang Jue
Department Of Pharmacognosy College Of Pharmacy Nihon University
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WANG Jue
Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
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Matsuzaki Keiichi
Department of Pharmacognosy, College of Pharmacy, Nihon University
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