Lignans from the Roots of Wikstroemia indica and Their DPPH Radical Scavenging and Nitric Oxide Inhibitory Activities
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概要
- 論文の詳細を見る
In our investigation of in vitro anti-allergic screening of medicinal herbal extracts, the ethyl acetate extract of the root of Wikstroemia indica was observed to inhibit nitric oxide (NO) production in a lipopolysaccharide (LPS) and recombinant mouse interferon-γ (IFN-γ) activated murine macrophage-like cell line, RAW 264.7. Fractionation of the active extract led to the isolation of two new lignan dimer bis-5, 5-nortrachelogenin (1) and bis-5, 5'-nortrachelogenin (2), and three known lignans. Compound 1 and lirioresinol B (5) inhibited NO production with IC_<50> values at 48.6 and 53.5μM, respectively. Compound 5 also showed free radical scavenging effect on 1, 1-diphenyl-2-picrylhydrazil (DPPH) at IC_<50> values at 19.5μM.
- 公益社団法人日本薬学会の論文
- 2005-10-01
著者
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WANG Li
Department of Biochemistry, Molecular Biology, and Cell Biology, Northwestern University
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KITANAKA Susumu
Department of Pharmacognosy, College of Pharmacy, Nihon University
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Kitanaka Susumu
Department Of Pharmacognosy College Of Pharmacy Nihon University
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Wang Li-yan
Coll. Of Pharmacy Nihon Univ.
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Wang Li-yan
Department Of Natural Products Chemistry Shenyang Pharmaceutical University
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UNEHARA Noriko
Department of Pharmacognosy, College of Pharmacy, Nihon University
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Wang Li
Department Of Automotive Engineering And State Key Lab Of Automotive Safety And Energy Tsinghua Univ
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Unehara Noriko
Department Of Pharmacognosy College Of Pharmacy Nihon University
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Wang Li
Department Of Applied Physics Beijing Polytechnic University
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