Formulation and Pharmacokinetic Evaluation of Tetracycline-Loaded Solid Lipid Nanoparticles for Subcutaneous Injection in Mice
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概要
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The aim of this work was to prepare tetracycline-loaded solid lipid nanoparticles (Tet-SLN), and to evaluate the potential of these colloidal carriers for subcutaneous injection. Tet-SLN was prepared by microemulsion method and the preparation conditions were optimized by ternary phase diagram. At optimized process conditions, lyophilized Tet-SLN showed spherical particles with a mean diameter of 87.2±46.9 nm and a negative zeta potential of −6.69 mV, up to 1.7% tetracycline drug content was achieved after loading. In vitro release test showed a biphasic release profile for Tet-SLN and more than 80% of the drug was liberated from Tet-SLN in 48 h. After subcutaneous injection of Tet-SLN to mice, a considerable sustained release was observed; tetracycline in blood could be detected lasting 36 h, and lower concentrations of tetracycline in all tissues tested compared to the free tetracycline solution were observed. In conclusion, Tet-SLN can be prepared well by microemulsion method and subcutaneous injection of SLN provide a new perspective for drug sustained release.
著者
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Yamashita Fumiyoshi
Department Of Drug Delivery Research Graduate School Of Pharmaceutical Sciences Kyoto University
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WANG Li
Department of Biochemistry, Molecular Biology, and Cell Biology, Northwestern University
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Xu Xi-ming
Department of Pharmaceutics, School of Pharmacy, Jiangsu University
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Wang Yan-song
Department of Pharmaceutics, School of Pharmacy, Jiangsu University
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Chen Rong-ying
Department of Pharmaceutics, School of Pharmacy, Jiangsu University
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Feng Chun-lai
Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University
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Yao Feng
Department of Surgery, Harvard Medical School, Brigham and Womens Hospital
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Tong Shan-shan
Department of Pharmaceutics, School of Pharmacy, Jiangsu University
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Yu Jiang-nan
Department of Pharmaceutics, School of Pharmacy, Jiangsu University
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Yao Feng
Department Of Breast And Thyroid Surgery Renmin Hospital Of Wuhan University
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Wang Li
Department Of Applied Physics Beijing Polytechnic University
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Yamashita Fumiyoshi
Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University
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Wang Li
Department of Pharmaceutics, School of Pharmacy, Jiangsu University
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