Anti-inflammatory Activity of New Guaiane Type Sesquiterpene from Wikstroemia indica

スポンサーリンク

概要

• 論文の詳細を見る

• In our investigation of in vitro anti-allergic screening of medicinal herbal extracts, the ethyl acetate extract of the root of Wikstroemia indica was observed to inhibit nitric oxide (NO) production in a lipopolysaccharide (LPS) and recombinant mouse interferon-γ (IFN-γ) activated murine macrophage-like cell line, RAW 264.7. Fractionation of the active extract led to the isolation of one new guaiane type sesquiterpene, indicanone (1), and two known biflavonoids, sikokianin B (2) and sikokianin C (3). 1 inhibited NO production with IC_<50> values at 9.3 μM and also inhibit the inducible nitric oxide synhase (iNOS) gene expression. This is the first report of NO production inhibitory activity of Wikstroemia indica and supports the pharmacological use of it, which has been employed as an herbal medicine for the treatment of inflammation.

• 公益社団法人日本薬学会の論文
• 2005-01-01

著者

• Wang L‐y

  Shenyang Pharmaceutical Univ. Shenyang Chn

• WANG Li-Yan

  Department of Pharmacognosy, College of Pharmacy, Nihon University

• UNEHARA Tomoko

  Department of Pharmacognosy, College of Pharmacy, Nihon University

• KITANAKA Susumu

  Department of Pharmacognosy, College of Pharmacy, Nihon University

• Kitanaka Susumu

  Department Of Pharmacognosy College Of Pharmacy Nihon University

• Wang Li-yan

  Department Of Natural Products Chemistry Shenyang Pharmaceutical University

• Unehara Tomoko

  Department Of Pharmacognosy College Of Pharmacy Nihon University

関連論文

• Anti-inflammatory Activity of New Guaiane Type Sesquiterpene from Wikstroemia indica
• Lignans from the Roots of Wikstroemia indica and Their DPPH Radical Scavenging and Nitric Oxide Inhibitory Activities
• Stilbene and dihydrophenanthrene derivatives from Pholidota chinensis and their nitric oxide inhibitory and radical-scavenging activities
• New Stilbenoids from Pholidota yunnanensis and Their Inhibitory Effects on Nitric Oxide Production
• Diterpenes from the Roots of Euphorbia kansui and Their in Vitro Effects on the Cell Division of Xenopus (2)
• Stilbene Derivatives from Pholidota chinensis and Their Anti-inflammatory Activity

スポンサーリンク