Diterpenes from the Roots of Euphorbia kansui and Their in Vitro Effects on the Cell Division of Xenopus (2)

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概要

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• Four new ingenane-type diterpenes, 3-O-(2,3-dimethylbutanoyl)-13-O-dodecanoyl-20-O-acetylingenol (1), 3-O-(2,3-dimethylbutanoyl)-13-O-dodecanoyl-20-deoxyingenol (2), 3-O-(2E,4Z-decadienoyl)-20-deoxyingenol (3), and 3-O-(2E,4E-decadienoyl)-20-deoxyingenol (4), two new jatrophane-type diterpenes, kansuinins D (9) and E (10), and four known ingenane-type diterpenes were isolated from the root of Euphorbia kansui. Their structures were elucidated by spectroscopic and chemical analysis, and individual Xenopus cells at the blastular stage were cultured with the diterpenes to test for biological activity. 20-Deoxyingenol diterpenes 3 and 4 induced the greatest cell cleavage arrest (0.5μg/ml of each compound resulted in >75% cleavage arrest), but cell cleavage inhibitory activity became weak when C-16 had an acyl residue. In contrast, the jatrophane diterpene kansuinin D (9) showed no activity.

• 公益社団法人日本薬学会の論文
• 2003-08-01

著者

• KITANAKA Susumu

  College of Pharmacy, Nihon University

• Yao Xin-sheng

  Medical College Jinan University

• Yao Xin

  Medical College Jinan University

• Yao Xin-sheng

  Department Of Natural Products Chemistry Shenyang Pharmaceutical University

• Wang Nai-li

  Dep. Of Natural Products Chemistry Shenyang Pharmaceutical Univ.

• Wang Nai-li

  Department Of Natural Products Chemistry Shenyang Pharmaceutical University

• Yao Xin-sheng

  College Of Traditional Chinese Materia Medica Shenyang Pharmaceutical University:shenzhen Research C

• WANG Li-Yan

  Department of Pharmacognosy, College of Pharmacy, Nihon University

• Kitanaka Susumu

  Res. Unit Of Pharmacognosy School Of Pharmacy Nihon Univ.

• Kitanaka Susumu

  College Of Pharmacy Nihon University

• Wang Li-yan

  Department Of Natural Products Chemistry Shenyang Pharmaceutical University

• Yao X‐s

  Inst. Of Traditional Chinese Medicine And Natural Products Jinan Univ.

• Yao X‐s

  Coll. Of Traditional Chinese Materia Medica Shenyang Pharmaceutical Univ.

• Yao Xin-sheng

  Department Of Immunology Zunyi Medical College

• Miyata Syohei

  Department of Chemistry, College of Humanities and Sciences, Nihon University

• Wang Nai-li

  Key Lab For New Drugs Res. Of Traditional Chinese Medicine Shenzhen Res. Inst. Of Tsinghua Univ.

• Miyata Syohei

  Department Of Chemistry College Of Humanities And Sciences Nihon University

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