Effects of Fructus Ligustri Lucidi Extract on Bone Turnover and Calcium Balance in Ovariectomized Rats(Pharmacology)
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概要
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The aim of this study was to evaluate the effect of Fructus Ligustri Lucidi (FLL), a kidney-tonifying Chinese herbal medicine, on the biochemical markers of bone turnover, calcium metabolism and balance in osteoporotic rat model developed by ovariectomy. Four weeks after surgical operation, animals were randomly assigned to one of the four treatments for 14 weeks: sham-operated control treated with vehicle (sham, n=8), ovariectomized group treated with vehicle (OVX, n=8), OVX group treated with 17β-estradiol (E_2, n=10, 2μg/kg/d) and OVX group treated with FLL extracts (FLL, n=10, 550mg/kg/d). Serum osteocalcin and urinary deoxypyridinoline levels were upregulated in rats in response to OVX, suggesting that the bone turnover rate was accelerated in these animals. Treatment of OVX rats with FLL extract could prevent OVX-induced increase in bone turnover by suppression of both serum osteocalcin (p<0.05, vs. OVX) and urinary deoxypyridinoline (p<0.05, vs. OVX) levels. In addition, FLL extract could prevent OVX-induced loss of calcium in rats by increasing the intestinal calcium absorption rate (p<0.01, vs. OVX), suppressing urinary Ca excretion (p<0.05, vs. OVX) as well as increasing bone calcium content (p<0.05, vs. OVX). Our study is the first to report that FLL can modulate bone turnover and calcium balance in OVX rats and it might be a potential candidate for prevention and treatment of postmenopausal osteoporosis.
- 公益社団法人日本薬学会の論文
- 2006-02-01
著者
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ZHANG Yan
Department Molecular Oral Medicine and Maxillofacial Surgery, Division of Frontier Medical Science,
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LAI Wan-Ping
State Key Laboratory of Chinese Medicine and Molecular Pharmacology
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LEUNG Ping-Chung
Department of Orthopaedics and Traumatology, the Chinese University of Hong Kong
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WU Chun-Fu
School of Pharmacy, Shenyang Pharmaceutical University
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WONG Man-Sau
State Key Laboratory of Chinese Medicine and Molecular Pharmacology
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Leung Ping-chung
Department Of Orthopaedics And Traumatology The Chinese University Of Hong Kong
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ZHANG Yan
State Key Laboratory of Chinese Medicine and Molecular Pharmacology
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Yao Xin
Medical College Jinan University
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Yao Xin-sheng
Inst. Of Traditional Chinese Medicine And Natural Products Jinan Univ.
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Yao Xin-sheng
School Of Traditional Chinese Materia Medicine Shengyang Pharmaceutical Univ.
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Wu Chun-fu
中華人民共和国
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Wu Chun-fu
School Of Pharmacy Shenyang Pharmaceutical University
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Wu Chun-fu
Department Of Pharmacology Shenyang Pharmaceutical University College Of Life Science And Biopharmac
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Wong Man-sau
Central Lab. Inst. Of Molecular Technol. For Drug Discovery And Synthesis Dep. Of Applied Biology An
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Wong Man-sau
Central Laboratory Institute Of Molecular Technology For Drug Discovery And Synthesis Department Of
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Lai Wan-ping
State Key Laboratory Of Chinese Medicine And Molecular Pharmacology:department Of Applied Biology An
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YAO Xin-Sheng
Joint Laboratory of Biotechnology and Drug Discovery, Graduate School at Shenzhen, Tsinghua Universi
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