Efficacy and Safety of Fasudil in Patients With Subarachnoid Hemorrhage : Final Results of a Randomized Trial of Fasudil Versus Nimodipine
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概要
- 論文の詳細を見る
Fasudil is believed to be at least equally effective as nimodipine for the prevention of cerebral vasospasm and subsequent ischemic injury in patients undergoing surgery for subarachnoid hemorrhage (SAH). We report the final results of a randomized, open trial to compare the efficacy and safety of fasudil with nimodipine. A total of 63 patients undergoing surgery for SAH received fasudil and 66 received nimodipine between 1998 and 2004. Symptomatic vasospasm, low density areas on computed tomography (CT), clinical outcomes, and adverse events were all recorded, and the results were compared between the fasudil and nimodipine groups. Absence of symptomatic vasospasm, occurrence of low density areas associated with vasospasm on CT, and occurrence of adverse events were similar between the two groups. The clinical outcomes were more favorable in the fasudil group than in the nimodipine group (p = 0.040). The proportion of patients with good clinical outcome was 74.5% (41/55) in the fasudil group and 61.7% (37/60) in the nimodipine group. There were no serious adverse events reported in the fasudil group. The present results suggest that fasudil is equally or more effective than nimodipine for the prevention of cerebral vasospasm and subsequent ischemic injury in patients undergoing surgery for SAH.
- 2011-10-15
著者
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ZHANG Yan
Department Molecular Oral Medicine and Maxillofacial Surgery, Division of Frontier Medical Science,
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Guo Jing
Department Of Biochemistry And Molecular Biology Nanjing Medical University
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Guo Jing
Department Of Neurosurgery China-japan Friendship Hospital
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Wang Shuo
Department Of Neurosurgery Capital Medical University Affiliated Beijing Tiantan Hospital
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Xu Bin
Department Of Urban And Civil Engineering Faculty Of Engineering Ibaraki University
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ZHAO Jizong
Department of Neurosurgery, Capital Medical University Affiliated Beijing Tiantan Hospital
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REN Zyuan
Department of Neurosurgery, Peking Union Medical College Hospital
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ZHOU Liangfu
Department of Neurosurgery, Shanghai Medical University Affiliated Huashan Hospital
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WANG Renzhi
Department of Neurosurgery, Peking Union Medical College Hospital
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Mao Ying
Department Of Chemistry Northwest Normal University
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Xu Bainan
Department Of Neurosurgery General Hospital Of The Cpla
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Wang Renzhi
Department Of Neurosurgery Peking Union Medical College Hospital
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Zhao Jizong
Department Of Neurosurgery Capital Medical University Affiliated Beijing Tiantan Hospital
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Zhou Liangfu
Department Of Neurosurgery Shanghai Medical University Affiliated Huashan Hospital
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Zhou Dingbiao
Department Of Neurosurgery General Hospital Of The Cpla
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Ren Zyuan
Department Of Neurosurgery Peking Union Medical College Hospital
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Zhang Yan
Department Of Neurosurgery Capital Medical University Affiliated Beijing Tiantan Hospital
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REN Zuyuan
Department of Neurosurgery, Peking Union Medical College Hospital
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ZHAO Kuiming
Department of Neurosurgery, China-Japan Friendship Hospital
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ZHANG Xiaolin
Asahi Kasei Corporation Beijing Office
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Mao Ying
Department Of Neurosurgery Shanghai Medical University Affiliated Huashan Hospital
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Zhao Kuiming
Department Of Neurosurgery China-japan Friendship Hospital
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Wang Renzhi
Department of Neurological Surgery, Kitasato University School of Medicine.
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