The In Vivo Effects of Indomethacin on Reactivity of the Rat Pial Arterioles

概要

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The effects of indomethacin, a potent cyclooxygenase inhibitor, on the diameter of the pial arterioles and their response to hypercarbia and bilateral common carotid occlusion were defined in vivo in rats. The pial arterioles with the diameter of 30-50 μm were directly observed in situ using the closed cranial window technique and video microscopy. Indomethacin (3mg/kg and 10mg/kg, i.v.) decreased the resting diameter of the pial arterioles by 4.8% and 4.6% (p<0.05) respectively with no change in systemic arterial pressure. Indomethacin did not either abolish or diminish the response to 5% carbon dioxide inhalation. Bilateral carotid occlusion produced 38.0% (p<0.001) increase in the diameter of the pial arterioles in the untreated control group, whereas in the group treated with 10mg/kg indomethacin only 11.1% (p<0.05) increase in the diameter was noted. Thus, indomethacin significantly (p<0.05) inhibited the dilatation of the pial arterioles during occlusion. Since indomethacin constricted the pial arterioles and attenuated vasodilatation induced by bilateral carotid occlusion, the present study supports the hypothesis that prostaglandins, cyclooxygenase products, may be partially involved in regulation of the cerebrovascular resting tone and possibly play roles in acute dilatation of the resistant vessels caused by major cerebral artery occlusion in rats.
北里大学の論文
1989-08-31