Activities of Antioxidant Enzymes Induced by Ethanol Exposure in Aldehyde Dehydrogenase 2 Knockout Mice
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概要
- 論文の詳細を見る
Acetaldehyde production during ethanol metabolism has been implicated as an important link between oxidative stress and cell damage, which suggests that oxidative stress caused by ethanol exposure may be more severe in aldehyde dehydrogenase 2 (ALDH2)-deficient individuals than in those with wild-type ALDH2. We evaluated the activities of the major antioxidant enzymes, superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx), in liver tissue isolated from Aldh2+/+ and Aldh2 -/- mice that were exposed to ethanol. The activities of CAT and GPx were significantly increased by ethanol treatment in Aldh2 +/+ mice (3.33-fold and 1.65-fold, respectively). The mean activity of SOD in Aldh2 +/+ mice was 1.46-fold that in the Aldh2 +/+ control group, but the difference was not statistically significant. In Aldh2 -/- mice, the activities of SOD and CAT were decreased and that of GPx was slightly increased after ethanol exposure, but the differences were not significant. We postulate that antioxidant enzyme expression after ethanol consumption may differ according to the intracellular level of acetaldehyde or free radicals, which in turn depends on the activity of ALDH2. These results suggest that the greater toxicity of ethanol in Aldh2 -/- mice than in Aldh2 +/+ mice may be due to decreased antioxidant enzyme expression.
- 公益社団法人日本薬学会の論文
- 2007-08-01
著者
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小山 倫浩
産業医科大学医学部衛生学
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Lee Chul-ho
Department Of Preventive Medicine And Medical Research Institute College Of Medicine Chungbuk Nation
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Lee Chung-jong
Dep. Of Preventive Medicine And Medical Res. Inst. Coll. Of Medicine Chungbuk National Univ.
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ZHANG Yan
Department Molecular Oral Medicine and Maxillofacial Surgery, Division of Frontier Medical Science,
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Kim Yong‐dae
Department Of Preventive Medicine College Of Medicine Chunbuk National University
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Kim Yong-dae
Department Of Preventive Medicine College Of Medicine Chunbuk National University
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Kang Jong-won
Department Of Preventive Medicine And Medical Research Institute College Of Medicine Chungbuk Nation
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KAWAMOTO Toshihiro
Department of Environmental Health, University of Occupational and Environmental Health
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Oyama Tsunehiro
Department Of Chest Surgery Kitakyushu Municipal Medical Center
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OGAWA Masanori
Department of Environmental Health, University of Occupational and Environmental Health
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ISSE Toyohi
Department of Environmental Health, University of Occupational and Environmental Health
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KIM Heon
Department of Preventive Medicine, College of Medicine, Chungbuk National University
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EOM Sang-Yong
Department of Preventive Medicine and Medical Research Institute, College of Medicine, Chungbuk Nati
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Lee Chung-Jong
Department of Preventive Medicine and Medical Research Institute, College of Medicine, Chungbuk Nati
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Kim Heon
Dep. Of Preventive Medicine Coll. Of Medicine Chunbuk National Univ.
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Kim Heon
Department Of Preventive Medicine College Of Medicine Chungbuk National University
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Kim Heon
Department Of Mechanical And Biomedical Engineering Kangwon National University
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Kim Y‐d
Univ. Occupational And Environmental Health Kitakyushu
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Kim Yong-dae
Department Of Computer And Communication Engineering Chungbuk National University
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Eom Sang-yong
Department Of Preventive Medicine And Medical Research Institute College Of Medicine Chungbuk Nation
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Zhang Yan
Department Of Preventive Medicine And Medical Research Institute College Of Medicine Chungbuk Nation
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Isse Toyohi
Department Of Environmental Health School Of Medicine University Of Occupational And Environmental H
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Osaki Toshiro
The Department Pf Surgery Ii School Of Medicine University Of Occupational And Environmental Health.
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Kawamoto Toshihiro
Department Of Environmental Health School Of Medicine University Of Occupational And Environmental H
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Kawamoto Toshihiro
Dep. Of Environmental Health Univ. Of Occupational And Environmental Health
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Ogawa Masanori
Department Of Environmental Health School Of Medicine University Of Occupational And Environmental H
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