THE METABOLISM OF TRICHLOROETHYLENE AND ITS METABOLITES IN THE PERFUSED LIVER
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概要
- 論文の詳細を見る
The metabolism of trichloroethylene (TRI) and its metabolites, chloral hyrate (CH), trichloroethanol (free-TCE) and trichloroacetic acid (TCA), were examined in the isolated perfused rat liver, to clarify the role of the liver in the metabolism of TRI. TRI was rapidly converted to TCE and TCA by the perfused liver. TCA was produced from TRI about 2.5 times greater than was total-TCE. CH was metabolized to TCE and TCA immediately. TCA was also a dominant metabolite of CH over total-TCE. TCE(free type) was speedily conjugated by the liver. A portion of TCE was converted to TCA. Less than 10% of these metabolites produced by the liver were excreted into the bile. Most of them appeared in the perfusate.
- 日本トキシコロジー学会の論文
- 1987-05-25
著者
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HOBARA Tatsuya
Departments of Public Health and Laboratory Medicine, Graduate School of Medicine, Yamaguchi Univers
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KOBAYASHI Haruo
Department of Electronic Engineering, Graduate School of Engineering, Gunma University
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Hobara Tatsuya
Department Of Public Health Yamaguchi University School Of Medicine
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KAWAMOTO Toshihiro
Department of Environmental Health, University of Occupational and Environmental Health
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Iwamoto Susumu
Department Of Public Health Yamaguchi University School Of Medicine
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Kobayashi Haruo
Department Of Electronic Engineering Faculty Of Engineering Gunma University
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Kawamoto Toshihiro
Department Of Environmental Health School Of Medicine University Of Occupational And Environmental H
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Kawamoto Toshihiro
Department Of Environmental Health School Of Medicine University Of Occupational And Environmental H
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Kawamoto Toshihiro
Department Of Public Health Yamaguchi University School Of Medicine
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SAKAI Tsunemi
Department of Public Health, Yamaguchi University School of Medicine
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IMAMURA Akihisa
Department of Pharmacy, Yamaguchi University School of Medicine
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KOSHIRO Akira
Department of Pharmacy, Yamaguchi University School of Medicine
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Koshiro Akira
Department Of Pharmaceutics Niigata College Of Pharmacy
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Koshiro Akira
Department Of Pharmacy Yamaguchi University School Of Medicine
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Sakai Tsunemi
Department Of Public Health Yamaguchi University
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Sakai Tsunemi
Department Of Public Health Yamaguchi University School Of Medicine
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Imamura Akihisa
Department Of Pharmacy Saiseikai Yamaguchi General Hospital
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Imamura Akihisa
Department Of Pharmacy Yamaguchi University School Of Medicine
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Kobayashi Haruo
Department Of Public Health Yamaguchi University School Of Medicine
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KOBAYASHI HARUO
Department of Animal Breeding, Faculty of Agriculture, University of Tokyo
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