The Effects of 1-Nitropyrene on Oxidative DNA Damage and Expression of DNA Repair Enzymes

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概要

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• Nitropyrenes (NPs) present in diesel and gasoline emissions are mutagenic and carcinogenic in experimental animals. Nitro-reduction of 1-NP causes oxidative stress. It is unclear whether 8-hydroxydeoxyguanosine (8-OH-dG) is produced from 1-NP and whether it contributes to the carcinogenic activity of 1-NP. In this study, we measured the level of reactive oxygen species (ROS) in cultured human lung epithelial cells after exposure to 1-NP and the intracellular level of 8-OH-dG and expression level of the 8-OH-dG repair enzymes. As results, 1-NP induced the generation of 8-OH-dG via ROS, but 8-OH-dG repair enzymes prevented an increase of 8-OH-dG formation in cellular DNA of the A549 cell line below 250 μM of 1-NP. These data suggest that 1-NP can induce oxidative DNA damage by generation of ROS, which may play a role in the carcinogenesis induced by 1-NP. These data also suggest that individuals with impaired DNA repair enzymes might be more susceptible to lung cancer induced by 1-NP.

• 社団法人日本産業衛生学会の論文

著者

• Kim Yong‐dae

  Department Of Preventive Medicine College Of Medicine Chunbuk National University

• Kim Yong-dae

  Department Of Preventive Medicine College Of Medicine Chunbuk National University

• KAWAMOTO Toshihiro

  Department of Environmental Health, University of Occupational and Environmental Health

• KIM Heon

  Department of Preventive Medicine, College of Medicine, Chungbuk National University

• Ko Young-Jun

  Department of Preventive Medicine & Medical Research Center, College of Medicine, Chungbuk National

• Kim Heon

  Dep. Of Preventive Medicine Coll. Of Medicine Chunbuk National Univ.

• Kim Heon

  Department Of Preventive Medicine College Of Medicine Chungbuk National University

• Kim Heon

  Department Of Mechanical And Biomedical Engineering Kangwon National University

• Kim Y‐d

  Univ. Occupational And Environmental Health Kitakyushu

• Kim Yong-dae

  Department Of Computer And Communication Engineering Chungbuk National University

• Ko Young-jun

  Department Of Preventive Medicine & Medical Research Center College Of Medicine Chungbuk Nationa

• Kawamoto Toshihiro

  Department Of Environmental Health School Of Medicine University Of Occupational And Environmental H

• Kawamoto Toshihiro

  Dep. Of Environmental Health Univ. Of Occupational And Environmental Health

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