Effects of Genetic Polymorphisms in Metabolic ENzymes on the Relationships between 8-hydroxydeoxyguanosine Levels in Human Leukocytes and Urinary 1-hydroxypyrene and 2-naphthol Concentrations
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概要
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Effects of Genetic Polymorphisms in Metabolic Enzymes on the Relationships between 8-hydroxydeoxyguanosine Levels in Human Leukocytes and Urinary 1-hydroxypyrene and 2-naphthol Concentrations: Yong-Dae KIM, et al. Department of Preventive edicine, College of Medicine, Chungbuk National University, South Korea-This study was designed to investigate the relationship between environmental exposure to polycyclic aromatic hydrocarbons (PAHs) and oxidative stress, and to evaluate the effects of cigarette smoking and the genetic polymorphisms of CYP1A1, CYP2E1, GSTM1, NAT2 and UGT1A6 on the relationship. The subjects of this study were 105 healthy Korean males without occupational exposure to PAHs. The 8-hydroxydeoxyguanosine (8-OHdG) level in leukocytes,and urinary 1-hydroxypyrene (1-OHP) and 2-naphthol concentrations, were measured by high-performance liquid chromatography. Genetic polymorphisms of CYP1A1, CYP2E1, GSTM1, M472and UGT1A6were identified by PCR and PCR-RFLP methods. The 8-OHdG level showed a significant correlation with the 1-OHP concentration in all subjects (p< .001) and in smokers (p< .01), and with the 2-naphthol level in nonsmokers (p< .01). The 8-OHdG level was significantly higher in smoking rapid acetylators than in smoking slow or intermediate acetylators, and in individuals with the UGT1A6 wild-type than in those with the UGT1A6 mutant genotype. Significant positive correlations between 8-OHdG and 1-OHP concentrations were found in subjects with every genotype of the CYP1A1 and CYP2E1 genes, with the GSTM1 null-type, with the NAT2 genotype of a rapid acetylator, and with the UGT1A6 wild-type, respectively. The urinary 2-naphthol level significantly correlated with the 8-OHdG level only in subjects with the GSTM1 null-type. In conclusion, there is a significant correlation between the 8-OHdG level in leukocytes and the urinary 1-OHP concentration in the population not occupationally exposed to PAHs. This relationship is affected by genetic polymorphisms in PAH metabolic enzymes.
- 社団法人日本産業衛生学会の論文
著者
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LEE Chul-Ho
Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine
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Lee Chul-ho
Department Of Preventive Medicine And Medical Research Institute College Of Medicine Chungbuk Nation
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Lee Chung-jong
Dep. Of Preventive Medicine And Medical Res. Inst. Coll. Of Medicine Chungbuk National Univ.
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Kim Yong‐dae
Department Of Preventive Medicine College Of Medicine Chunbuk National University
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Kim Yong-dae
Department Of Preventive Medicine College Of Medicine Chunbuk National University
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Nan Hong-mei
Department Of Preventive Medicine College Of Medicine Chungbuk National University
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Kang Jong-won
Department Of Preventive Medicine And Medical Research Institute College Of Medicine Chungbuk Nation
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Lee Chul-ho
Department Of Occupational And Environmental Health Nagoya University Graduate School Of Medicine
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KIM Heon
Department of Preventive Medicine, College of Medicine, Chungbuk National University
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Kim Heon
Dep. Of Preventive Medicine Coll. Of Medicine Chunbuk National Univ.
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Kim Heon
Department Of Preventive Medicine College Of Medicine Chungbuk National University
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Kim Heon
Department Of Mechanical And Biomedical Engineering Kangwon National University
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Kim Y‐d
Univ. Occupational And Environmental Health Kitakyushu
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Kim Yong-dae
Department Of Computer And Communication Engineering Chungbuk National University
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