Urothelial Cancer Risk in Relation to Genotypes of Glutathione S-Transferase (GST) M1, T1, P1 and N-Acetyltransferase 2 (NAT2), and Tobacco Smoking
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概要
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Both genetic and environmental factors are involved in the development of cancer. Molecular epidemiological studies were performed in order to elucidate the relationship between four polymorphic metabolic enzymes and susceptibility to urothelial cancer (bladder, renal pelvis and ureter) and cigarette-smoking. The polymorphisms of glutathione S-transferase (GST) M1, T1 and P1, and N-acetyltransferase (NAT) 2 were analyzed by PCR, and a history of cigarette smoking was obtained through an interview with 102 cancer cases and with 100 controls. GSTM 1 null genotype was a risk factor (odds ratio (OR), 2.12; 95% confidence interval (Cl), 1.17-3.90), especially in smokers (OR, 3.70; 95%Cl, 1.16-12.79). GSTT1 null genotype and the polymorphism of GSTP1 at nucleotide 313 were not associated with the cancer risk. Slow acetylation genotype of NAT2 was a significant risk factor (OR, 4.75; 95%Cl, 1.64-15.90) in overall samples and the greatest risk for smokers (OR, 10.05; 95% Cl, 1.08-240.6). To investigate the relationship between the cancer and the amount of smoking, we performed regression analysis for the relative risk of cancer as a function of the amount of smoking. The regression analysis shows that the susceptibility of people who have the GSTM1 null genotype or NAT2 intermediate acetylator genotype is easily raised by a little smoking compared to the GSTM1 positive genotype or NAT2 rapid acetylation genotype, respectively. These results imply that polymorphisms in the GSTM1 and NAT2 gene are a genetic determinant of urothelial cancer among Japanese, and the interaction between genes and cigarette smoking may be important in the development of urothelial cancer.
- 社団法人日本産業衛生学会の論文
著者
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KATOH Takahiko
Department of Public Health, Faculty of Life Sciences, Kumamoto University
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Kosugi Takayoshi
Department Of Pharmacy National Cardiovascular Center
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Kotake Takeshi
国立循環器病センター 薬剤部
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Kubo Takashi
Project Team For Pharmacogenetics National Institute Of Health Sciences
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MATSUMOTO Tetsuro
Department of Urology, University of Occupational and Environmental Health
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NAKANO Masahiro
Department of Physics, Kyoto University
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Nakano Masahiro
熊本大学医学部附属病院 薬剤
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Katoh Takahiko
宮崎大学 医学部免疫感染病態学
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Katoh Takahiko
Department Of Biochemistry School Of Medicine University Of Occupational And Environmental Health
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INATOMI Hisato
Department of Urology, University of Occupational and Environmental Health
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KAWAMOTO Toshihiro
Department of Environmental Health, University of Occupational and Environmental Health
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YOSHIOKA Makoto
Department of Health Information Science, School of Health Sciences, University of Occupational and
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Nakano M
Department Of Information Science University Of Occupational And Environmental Health
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Nakano M
University Of Occupational And Environmental Health
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Nakano M
Department Of Biologicalsciences Teikyo University Of Science And Technology
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Nakano Masahiro
Department Of Biologicalsciences Teikyo University Of Science And Technology
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Matsumoto Tetsuro
Department Of Urology School Of Medicine University Of Occupational And Environmental Health
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Inatomi Hisato
Asian Clinical Research Group
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Inatomi Hisato
Department Of Urology University Of Occupational And Environmental Health
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Matsumoto T
Division Of Advanced Technology For Medical Imaging National Institute Of Radiological Science
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Kawamoto Toshihiro
Department Of Environmental Health School Of Medicine University Of Occupational And Environmental H
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Kawamoto Toshihiro
Department Of Environmental Health School Of Medicine University Of Occupational And Environmental H
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Yoshioka Makoto
Department Of Health Information Science School Of Health Sciences
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Inatomi Hisato
Department Of Epidemiology National Institute Of Public Health
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Nakano M
Univ. Occupational And Environmental Health Jpn
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Katoh T
Univ. Occupational And Environmental Health
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Matsumoto Tetsuro
Japanese Society Of Chemotherapy (jsc)
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Matsumoto Tetsuro
Department Of University Of Occupational And Environmental Health
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Nakano Masahiro
Deparment Of Physics Kyushu University
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NAKANO Masahiro
Department of Physics, Kyushu University:Department of Physics, Saga University
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