Genetic Polymorphisms of CYP2A6 and CYP2E1 with Tobacco Smoking is not Associated with Risk of Urothelial Cancer

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概要

• 論文の詳細を見る

• Objectives : To elucidate the association between genetic polymorphisms of CYP2A6 and CYP2E1 and urothelial cancer susceptibility. Methods : A total of 137 Japanese patients with urothelial cancer and 217 Japanese healthy controls, frequency-matched for age and gender, were selected. The polymorphisms of CYP2A6 and CYP2E1 were analyzed by PCR-RFLP, and cigarette smoking histories were obtained through interviews. Results : The frequency of CYP2A6 homozygote deletion genotype was 2.9% in the patients, compared with 3.2% in the controls (OR=0.84, 95% CI 0.24-2.96). The frequencies of CYP2E1 C1/c2 and C2/c2 were 27.7% and 4.4% in the patients, compared with 35.5% and 6.0% in the controls (OR=0.68, 95% CI 0.42-1.09, OR=0.67, 95% CI 0.24-1.84, respectively). No statistically significant differences were observed when the CYP2A6 homozygote deletion genotype and the CYP2E1 genotypes were examined relative to smoking status. Conclusions : Our data indicate that neither a relationship between genetically impaired nitrosamine metabolism and tobacco-smoking consumption, nor urothelial cancer risk related to the CYP2A6 deletion genotype and CYP2E1 Rsa I genotype was found in Japanese population.

• 日本衛生学会の論文

著者

• KATOH Takahiko

  Department of Public Health, Faculty of Life Sciences, Kumamoto University

• KITAGAWA Kyoko

  Department of Biochemistry 1, Hamamatsu University School of Medicine

• Kosugi Takayoshi

  Department Of Pharmacy National Cardiovascular Center

• Kosugi Takayoshi

  東邦大学医学部附属大森病院 薬剤

• Kotake Takeshi

  国立循環器病センター 薬剤部

• Kubo Takashi

  Project Team For Pharmacogenetics National Institute Of Health Sciences

• Kotake Takeshi

  国立医薬品食品衛生研究所

• Nakao Hiroyuki

  Department of Emergency and Disaster Medicine, Kobe University Graduate School of Medicine

• Katoh Takahiko

  宮崎大学 医学部免疫感染病態学

• Katoh Takahiko

  Department Of Biochemistry School Of Medicine University Of Occupational And Environmental Health

• Nakao Hiroyuki

  宮崎大学 医学部免疫感染病態学

• Nakao Hiroyuki

  Department Of Epidemiology National Institute Of Public Health

• Nakao Hiroyuki

  Department Of Emergency And Disaster Medicine Kobe University Graduate School Of Medicine

• TSUKINO Hiromasa

  Department of Urology, Miyazaki Medical College

• KURODA Yoshiki

  Department of Public Health, Miyazaki Medical College

• IMAI Hirohisa

  Department of Public Health, Miyazaki Medical College

• OSADA Yukio

  Department of Urology, Miyazaki Medical College

• INATOMI Hisato

  Department of Urology, University of Occupational and Environmental Health

• KAWAMOTO Toshihiro

  Department of Environmental Health, University of Occupational and Environmental Health

• Kitagawa Kyoko

  Department Of Biochemistry 1 Hamamatsu University School Of Medicine

• Imai Hirohisa

  Department Of Epidemiology National Institute Of Public Health

• Imai Hirohisa

  Department Of Public Health Miyazaki Medical College

• Osada Yukio

  Department Of Urology Miyazaki Medical College

• Inatomi Hisato

  Asian Clinical Research Group

• Inatomi Hisato

  Department Of Urology University Of Occupational And Environmental Health

• Takemura Kazuo

  Liberal Arts And Basic Sciences College Of Industrial Technology Nihon University

• Kuroda Yoshiki

  Division Of Public Health Department Of Social Medicine Faculty Of Medicine University Of Miyazaki

• Kawamoto Toshihiro

  Department Of Environmental Health School Of Medicine University Of Occupational And Environmental H

• Kawamoto Toshihiro

  Department Of Environmental Health School Of Medicine University Of Occupational And Environmental H

• Inatomi Hisato

  Department Of Epidemiology National Institute Of Public Health

• Tsukino Hiromasa

  Department Of Urology Miyazaki Medical College:department Of Public Health Miyazaki Medical College

• Tsukino Hiromasa

  Department Of Urology Miyazaki Medical College University Of Miyazaki

• Katoh T

  Univ. Occupational And Environmental Health

• Nakao Hiroyuki

  Department Of Anesthesiology Akashi Municipal Hospital

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