Application of aldehyde dehydrogenase 2 (ALDH2) Genetic Diagnosis in Support of Decreasing Alcohol Intake

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概要

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• Encouraging behavioral changes to decrease alcohol intake is not easy from the standpoint of health support. This study was conducted to examine whether the genetic diagnosis of ALDH2 polymorphism is useful in supporting those who want to decrease their alcohol intake. The participants in this study were 329 male employees who wanted to know the result of their ALDH2 genotype. We divided the 329 participants randomly into two groups. One was the "notified group" (n=157), and the other was the "non-notified group" (n=172). The subjects belonging to the "notified group" were informed of the results of the ALDH2 genotype diagnosis in April, 2003. Drinking habits and laboratory data were obtained before and after notification of the ALDH2 genotype. Among those with genotype ALDH2 1/1, there was no significant change in drinking frequencies, nor was there any significant decline in liver function laboratory data in either of the groups before and after notification of the genotype. However, weekly alcohol intake tended to increase compared to that before notification. On the other hand, with regard to those with genotype ALDH2 1/2, no significant changes in drinking frequencies or liver function laboratory data were evident in either group before and after notification of the genotype. However, the weekly alcohol intake tended to increase in the non-notified group, whereas it tended to decrease in the notified group. Although the result was not significant, it is suggested that, with further study and an increased sample size, the genetic diagnosis may be found to be useful.

• 社団法人日本産業衛生学会の論文

著者

• Kosugi Takayoshi

  Department Of Pharmacy National Cardiovascular Center

• Kosugi Takayoshi

  東邦大学医学部附属大森病院 薬剤

• Kotake Takeshi

  国立循環器病センター 薬剤部

• Kubo Takashi

  Project Team For Pharmacogenetics National Institute Of Health Sciences

• Kotake Takeshi

  国立医薬品食品衛生研究所

• Katoh Takahiko

  宮崎大学 医学部免疫感染病態学

• Nakahara Ai

  Dep. Of Public Health Miyazaki Medical Coll. Univ. Of Miyazaki

• Nakao Hiroyuki

  宮崎大学 医学部免疫感染病態学

• Nakao Hiroyuki

  Department Of Epidemiology National Institute Of Public Health

• KOMIYA Yasuhiro

  Division of Public Health, Department of Social Medicine, Faculty of Medicine, University of Miyazak

• NAKAO Hiroyuki

  Division of Public Health, Department of Social Medicine, Faculty of Medicine, University of Miyazak

• KURODA Yoshiki

  Division of Public Health, Department of Social Medicine, Faculty of Medicine, University of Miyazak

• ARIZONO Katsuyuki

  Division of Public Health, Department of Social Medicine, Faculty of Medicine, University of Miyazak

• NAKAHARA Ai

  Division of Public Health, Department of Social Medicine, Faculty of Medicine, University of Miyazak

• KATOH Takahiko

  Division of Public Health, Department of Social Medicine, Faculty of Medicine, University of Miyazak

• Katoh Takahiko

  Dep. Of Public Health Miyazaki Medical Coll. Univ. Of Miyazaki

• Nakao Hiroyuki

  Division Of Public Health Department Of Social Medicine Faculty Of Medicine University Of Miyazaki

• Katoh Takahiko

  Division Of Public Health Department Of Social Medicine Faculty Of Medicine University Of Miyazaki

• Takemura Kazuo

  Liberal Arts And Basic Sciences College Of Industrial Technology Nihon University

• Kuroda Yoshiki

  Division Of Public Health Department Of Social Medicine Faculty Of Medicine University Of Miyazaki

• Kawamoto Toshihiro

  Department Of Environmental Health School Of Medicine University Of Occupational And Environmental H

• Katoh T

  Univ. Occupational And Environmental Health

• Arizono Katsuyuki

  Division Of Public Health Department Of Social Medicine Faculty Of Medicine University Of Miyazaki

• Nakao Hiroyuki

  Division Of Biomaterials Science Graduate School Of Dentistry Osaka University

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