The Role of Dihydropyrazines in Accelerated Death of Escherichia coli on Addition of Copper (II)(Molecular and Cell Biology)
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概要
- 論文の詳細を見る
Dihydropyrazines (DHPs), which are derived from sugars, inhibit the growth of Escherichia coli. Addition of copper (II) ion (Cu^<2+>) accelerates the effect of DHPs, resulting in cell death. Investigation of the lethal effect in several DNA repair-deficient or detoxifying enzyme-deficient mutant strains and radical scavengers suggested that the cytotoxic and genotoxic damage was caused by radical species (hydroxyl, superoxide anion, and carboncentered radicals) generated from reaction of DHPs with Cu^<2+>.
- 公益社団法人日本薬学会の論文
- 2005-07-01
著者
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KATOH Takahiko
Department of Public Health, Faculty of Life Sciences, Kumamoto University
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Katoh Takahiko
Dep. Of Public Health Fac. Of Life Sciences Kumamoto Univ.
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Katoh Takahiko
Department Of Biochemistry School Of Medicine University Of Occupational And Environmental Health
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TAKEDA Osamu
Department of Public Health, Faculty of Medicine, University of Miyazaki
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YAMAGUCHI Tadatoshi
Faculty of Pharmaceutical Sciences, Sojo University
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YAMAGUCHI Tadatoshi
Department of Hygiene, Miyazaki Medical College
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Yamaguchi Tokio
Faculty Of Pharmaceutical Sciences Sojo University
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Yamaguchi T
Tsumura Res. Laboratories Tsumura & Co.
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Takeda Osamu
Department Of Public Health Faculty Of Medicine University Of Miyazaki
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Takechi Shinji
Dept. Biochem. Miyazaki Med. Coll.
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TAKECHI Shinji
Department of Hygiene, Miyazaki Medical College
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Tadatoshi Yamaguchi
Faculty Of Hygiene Miyazaki Medical College
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Yamaguchi Tadatoshi
Faculty Of Pharmaceutical Sciences Sojo University
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Takeda Osamu
Department of Materials Science and Technology, Faculty of Engineering, Niigata University
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