Twelve-year Cumulative Incidence of Airflow Obstruction among Japanese Males
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概要
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Background To date, there is very limited longitudinal data on COPD and incidence estimates in Japan. The aim of this study was to investigate the 12-year cumulative incidence of airflow obstruction (COPD) in Japanese males. Methods This study included 913 male subjects, aged 30-76 years, who underwent lung function tests at a medical check-up in 1994 (baseline), 1999, and 2006. The study group consisted of 263 persistent never smokers, 296 early quitters, 117 late quitters, and 237 persistent smokers without airflow obstruction at baseline. The 12-year cumulative incidence of airflow obstruction was estimated. The spirometric criteria for diagnosis of airflow obstruction were forced expiratory volume in 1 second (FEV1)/forced vital capacity (FVC) of <0.7 and 5th percentile lower limit of normal (FEV1/FVC<LLN). Results The 12-year cumulative incidences of airflow obstruction using fixed criteria and LLN criteria were 5.3%, 7.6% in persistent never smokers, 10.5%, 10.1% in early quitters, 12.0%, 14.5% in late quitters, 13.5%, 17.3% in persistent smokers, respectively. In logistic regression models, the odds ratio (OR) of developing airflow obstruction defined using the fixed criteria and the LLN criteria increased with a history of smoking status and increasing pack-years of smoking. When using the LLN criteria to define obstruction compared with fixed criteria, higher incidence rates among aged <60 and lower incidence rates among aged ≥60 were observed. Conclusion The cumulative incidence of airflow obstruction defined using the fixed ratio and LLN criteria was strongly associated with smoking status. This study suggested that early cessation of smoking may prevent the development of airflow obstruction among smokers.
著者
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Funakoshi Yayoi
Department Of Public Health Faculty Of Life Sciences Kumamoto University
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Katoh Takahiko
Department Of Biochemistry School Of Medicine University Of Occupational And Environmental Health
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Omori Hisamitsu
Department Of Public Health Faculty Of Life Sciences Kumamoto University
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Aizawa Hisamichi
Division Of Respirology Neurology And Rheumatology Department Of Internal Medicine Kurume University
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MIHARA Shuichi
Japanese Red Cross Kumamoto Health Care Center
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Onoue Ayumi
Department Of Public Health Faculty Of Life Sciences Kumamoto University
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Kohrogi Hirotsugu
Department Of Respiratory Medicine Graduate School Of Medical Sciences Kumamoto University
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Katoh Takahiko
Department of Public Health, Faculty of Life Sciences, Kumamoto University, Japan
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Kohrogi Hirotsugu
Department of Respiratory Medicine, Kumamoto University, Japan
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Onoue Ayumi
Department of Public Health, Faculty of Life Sciences, Kumamoto University, Japan
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Nagano Megumi
Kumamoto Health Science University, Japan
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Marubayashi Tohru
Japanese Red Cross Kumamoto Health Care Center, Japan
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Marubayashi Tohru
Japanese Red Cross Kumamoto Health Care Center
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Omori Hisamitsu
Department of Public Health, Faculty of Life Sciences, Kumamoto University, Japan
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Funakoshi Yayoi
Department of Public Health, Faculty of Life Sciences, Kumamoto University, Japan
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