Synthesis of New Dihydropyrazines with DNA Strand-Breakage Activity
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概要
- 論文の詳細を見る
Treatment of 1,2-cyclohexanedione with 1,2-diamines, e.g. ethylenediamine and cis-(and trans-)1,2-diaminocyclohexane, caused [4+2] cyclocondensation to give the corresponding dihydropyrazine derivatives (compounds 1-6). They exhibited stronger DNA strand-breakage activity than that of dihydropyrazines, which has already been reported in previous papers.
- 公益社団法人日本薬学会の論文
- 2005-10-01
著者
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YAMAGUCHI Tadatoshi
Faculty of Pharmaceutical Sciences, Sojo University
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KASHIGE Nobuhiro
Faculty of Pharmaceutical Sciences, Fukuoka University
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MIAKE Fumio
Faculty of Pharmaceutical Sciences, Fukuoka University
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Yamaguchi Tokio
Faculty Of Pharmaceutical Sciences Sojo University
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Miake F
Faculty Of Pharmaceutical Sciences Fukuoka University
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Miake Fumio
Faculty Of Pharmaceutical Sciences Fukuoka University
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MARUOKA Hiroshi
Faculty of Pharmaceutical Sciences, Fukuoka University
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Maruoka Hiroshi
Faculty Of Pharmaceutical Sciences Fukuoka University
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Tadatoshi Yamaguchi
Faculty Of Hygiene Miyazaki Medical College
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Yamaguchi Tadatoshi
Faculty Of Pharmaceutical Sciences Sojo University
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Kashige Nobuhiro
Faculty Of Pharmaceutical Sciences Fukuoka University
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Miake Fumio
Faculty of Pharmaceutical Science, Fukuoka University
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Yamaguchi Tadatoshi
Faculty of Pharmaceutical Science, Sojo University
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Kashige Nobuhiro
Faculty of Pharmaceutical Science, Fukuoka University
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