DNA Strand Scission by D-Glucosamine and Its Phosphates in Plasmid pBR322(Biological Chemistry)

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概要

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• DNA strand scission due to aminosugars and their derivatives in plasmid pBR322 was investigated through agarose gel electrophoresis. D-Glucosamine and its related aminosugars primarily caused single-strand scission of ccc-DNA to form oc-DNA in a time- and temperature-dependent manner. The degree of reaction was also related to the concentration of aminosugars. D-Glucosamine-6-phosphate was the most active among the compounds tested, and converted oc-DNA into linear-DNA and further fragmented DNA. The reaction was stimulated by Cu^<2+> and inhibited by catalase, superoxide dismutase, and some radical scavengers. The DNA strand-scissoring activities of aminosugars were related to their nitroblue tetrazolium-reducing activities. These results support a hypothetic mechanism in which some free radicals, generated during autoxidation of aminosugars in aqueous solution, are involved in DNA strand scission.

• 社団法人日本農芸化学会の論文
• 1986-06-23

著者

• Watanabe K

  Faculty Of Pharmaceutical Science School Of Medicine Fukuoka University

• KASHIGE Nobuhiro

  Faculty of Pharmaceutical Sciences, Fukuoka University

• WATANABE Kenji

  Faculty of Pharmaceutical Sciences, Fukuoka University

• NAKASHIMA Yukihiko

  Faculty of Pharmaceutical Sciences, Fukuoka University

• HAYASHIDA Mikie

  Faculty of Pharmaceutical Sciences, Fukuoka University

• SUMOTO Kunihiro

  Faculty of Pharmaceutical Sciences, Fukuoka University

• Watanabe Katsunori

  Department Of Bioresources Chemistry Faculty Of Horticulture Chiba University

• Watanabe K

  Research Institute For Food Science Kyoto University:(present Address)department Of Agricultural Che

• Watanabe K

  Marine Biotechnol. Inst. Iwate Jpn

• Sumoto Kunihiro

  Faculty Of Pharmaceutical Sciences Fukuoka University

• Kashige Nobuhiro

  Faculty Of Pharmaceutical Sciences Fukuoka University

• Hayashida Mikie

  Faculty Of Pharmaceutical Sciences Fukuoka University

• Nakashima Yukihiko

  Faculty Of Pharmaceutical Sciences Fukuoka University

• Watanabe Kenji

  Faculty Of Fisheries Kagoshima University

• Sumoto Kunihiro

  Faculty of Pharmaceutical Science, Fukuoka University

• Kashige Nobuhiro

  Faculty of Pharmaceutical Science, Fukuoka University

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