Synthesis of 2, 2'-Dihydroxybisphenols and Antiviral Activity of Some Bisphenol Derivatives

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概要

• 論文の詳細を見る

• New diphenylmethane-type 2, 2'-dihydroxybisphenols(5a-d)were prepared regioselectively in good yields. We evaluated the antiviral activity of some bisphenol derivatives synthesized by the plaque reduction assay. Most of the compounds showed significant antiviral activity and the 4, 4'-dihydroxybisphenol derivative(10)showed higher activity than 2, 2'-bisphenol derivatives. This compound had EC_<50> value of 1.8μg/ml.

• 公益社団法人日本薬学会の論文
• 2002-02-01

著者

• Mibu N

  Faculty Of Pharmaceutical Sciences Fukuoka University

• YOKOMIZO Kazumi

  Faculty of Medical and Pharmaceutical Sciences, Kumamoto University

• UYEDA Masaru

  Faculty of Medical and Pharmaceutical Sciences, Kumamoto University

• Uyeda Masaru

  Dep. Of Nutrition Sci. Facultiy Of Living Sci. Shokei Univ.

• Uyeda Masaru

  Laboratory Of Pharmaceutical Microbiology Faculty Of Medical And Pharmaceutical Sciences Kumamoto Un

• Uyeda Masaru

  Shokei University

• Yokomizo K

  Kumamoto Univ. Kumamoto Jpn

• Udayama M

  Kumamoto Univ. Kumamoto Jpn

• Mibu Nobuko

  Faculty Of Pharmaceutical Sciences Fukuoka University

• Yokomizo Kazumi

  Laboratory Of Pharmaceutical Microbiology Faculty Of Medical And Pharmaceutical Sciences Kumamoto Un

• Yokomizo Kazumi

  Faculty Of Pharmaceutical Sciences Kumamoto University

• SUMOTO Kunihiro

  Faculty of Pharmaceutical Sciences, Fukuoka University

• Udayama Manabu

  Faculty Of Pharmaceutical Sciences Kumamoto University

• Uyeda Masaru

  Department Of Pharmaceutical Microbiology Faculty Of Medical And Pharmaceutical Sciences Kumamoto Un

• Sumoto K

  Faculty Of Pharmaceutical Sciences Fukuoka University

• Sumoto Kunihiro

  Fukuoka Univ. Fukuoka Jpn

• Sumoto Kunihiro

  Faculty Of Pharmaceutical Sciences Fukuoka University

• Sumoto Kunihiro

  Faculty of Pharmaceutical Science, Fukuoka University

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