ANDP-7, a Novel Acrinol Degradation Product by Light

概要

論文の詳細を見る
To clarify the degradation pathway of acrinol by light, isolation and identification of acrinol degradation products (ANDP) were attempted. A novel acrinol degradation product, ANDP-7, one of the ANDPs, was isolated by extraction with methanol from cloths dampened with acrinol solution, and purified by column chromatography on Diaion HP-10 and Sephadex LH-20. The structural elucidation of ANDP-7 was examined by ^1H-NMR, ^<13>C-NMR and EI-mass spectra sudies. From the spectroscopic data, the structure of ANDP-7 was determined to be 9-amino-7-ethoxypyrrolo [3, 4-b] quinoline-1, 3-dione, that was found to be a novel degradation product of acrinol by light. Antimicrobial activities of ANDP-7 against Gram-positive and -negative bacteria were 5 to 100-fold higher than those of acrinol. ANDP-7 was also active against yeast and fungi. Nevertheless, acrinol did not show growth inhibition even at a concentration 100 μg/ml.
公益社団法人日本薬学会の論文
2005-02-01