Microbial Degradation of Disinfectants. A New Chlorhexidine Degradation Intermediate (CHDI), CHDI-C, Produced by Pseudomonas sp. Strain No. A-3
スポンサーリンク
概要
- 論文の詳細を見る
To clarify the degradation pathway of chlorhexidine by a microbe, Pseudomonas sp. Strain No. A-3, the isolation and identification of microbial chlorhexidine degradation products were attempted. A new chlorhexidine degradation intermediate (CHDI), named CHDI-C, was isolated by extraction with ethylacetate, n-butanol, column chromatography using Silica gel, and purified by preparative thin layer chromatography. The chemical structure of this product was examined by infrared, ^1H NMR, ^<13>C NMR and fast atom bombardment mass spectra studies. Based on the spectroscopic data, this product was assumed to be a modified compound of chlorhexidine (molecular weight, MW; 530). From the proposed structure, CHDI-C was assumed to be a new chlorhexidine degradation intermediate.
- 公益社団法人日本薬学会の論文
- 2005-06-01
著者
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Yokoi Kaori
School Of Agriculture Kyushu Tokai University
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Yokomizo K
Kumamoto Univ. Kumamoto Jpn
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Yokomizo Kazumi
Laboratory Of Pharmaceutical Microbiology Faculty Of Medical And Pharmaceutical Sciences Kumamoto Un
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Yokomizo Kazumi
Faculty Of Pharmaceutical Sciences Kumamoto University
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Kido Y
Div. Of Instrumental Analysis Inst. Of Resource Dev. And Analysis Kumamoto Univ.
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Matsuo Yasuko
Laboratory Of Medicinal Microbiology Faculty Of Pharmaceutical Sciences Kumamoto University
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Tanaka Teruo
Division of Instrumental Analysis, Institute of Resource Development and Analysis, Kumamoto Universi
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Kido Yutaka
Division of Instrumental Analysis, Institute of Resource Development and Analysis, Kumamoto Universi
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Tanaka Teruo
熊本大学生命資源研究･支援センター 機器分析分野
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Murayama Sawa
Division of Instrumental Analysis, Institute of Resource Development and Analysis
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Tuda Natuki
Division of Instrumental Analysis, Institute of Resource Development and Analysis
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Nishiyama Masami
Division of Instrumental Analysis, Institute of Resource Development and Analysis
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Nakagawa Kazuko
Laboratory of Medicinal Microbiology, Faculty of Pharmaceutical Sciences, Kumamoto University
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Isohama Youichiro
Laboratory of Medicinal Microbiology, Faculty of Pharmaceutical Sciences, Kumamoto University
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Tuda Natuki
Division Of Instrumental Analysis Institute Of Resource Development And Analysis
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Murayama Sawa
Division Of Instrumental Analysis Institute Of Resource Development And Analysis
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Kido Y
Faculty Of Pharmaceutical Sciences Kumamoto University
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Nakagawa Kazuko
Laboratory Of Medicinal Microbiology Faculty Of Pharmaceutical Sciences Kumamoto University
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Nishiyama Masami
Division Of Instrumental Analysis Institute Of Resource Development And Analysis Kumamoto University
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Isohama Youichiro
Laboratory Of Medicinal Microbiology Faculty Of Pharmaceutical Sciences Kumamoto University
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Kido Y
Ube Research Laboratory Fujirebio Inc.
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Tanaka Teruo
Division of Instrumental Analysis, Institute of Resource Development and Analysis, Kumamoto University
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