Synthesis and Antiviral Activities of Some 4,4'-Dihydroxytriphenylmethanes

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概要

• 論文の詳細を見る

• 4,4'-Dihydroxytriphenylmethanes were synthesized using Bronsted acid or Lewis acid in yields of 24-86% as target compounds for developing antiviral agents. Most of the 4,4'-dihydroxytriphenylmethanes showed significant activity against herpes simplex virus type 1 (anti-HSV-1 activity) in a plaque reduction assay. Higher cyto-toxicity was observed generally in halogenated 4,4'-dihydroxytriphenylmethanes (2a-d) than in non-halogenated derivatives. The non-halogenated derivative, 4,4',4"-trihydroxy-3"-methoxytriphenylmethane (3), showed remarkable antiviral activity with an EC_<50> value of 1.8 μg/ml.

• 公益社団法人日本薬学会の論文
• 2003-11-01

著者

• Mibu N

  Faculty Of Pharmaceutical Sciences Fukuoka University

• YOKOMIZO Kazumi

  Faculty of Medical and Pharmaceutical Sciences, Kumamoto University

• UYEDA Masaru

  Faculty of Medical and Pharmaceutical Sciences, Kumamoto University

• Uyeda Masaru

  Dep. Of Nutrition Sci. Facultiy Of Living Sci. Shokei Univ.

• Uyeda Masaru

  Laboratory Of Pharmaceutical Microbiology Faculty Of Medical And Pharmaceutical Sciences Kumamoto Un

• Uyeda Masaru

  Shokei University

• Yokomizo K

  Kumamoto Univ. Kumamoto Jpn

• Udayama M

  Kumamoto Univ. Kumamoto Jpn

• Mibu Nobuko

  Faculty Of Pharmaceutical Sciences Fukuoka University

• Yokomizo Kazumi

  Laboratory Of Pharmaceutical Microbiology Faculty Of Medical And Pharmaceutical Sciences Kumamoto Un

• Yokomizo Kazumi

  Faculty Of Pharmaceutical Sciences Kumamoto University

• SUMOTO Kunihiro

  Faculty of Pharmaceutical Sciences, Fukuoka University

• Udayama Manabu

  Faculty Of Pharmaceutical Sciences Kumamoto University

• Uyeda Masaru

  Department Of Pharmaceutical Microbiology Faculty Of Medical And Pharmaceutical Sciences Kumamoto Un

• Sumoto K

  Faculty Of Pharmaceutical Sciences Fukuoka University

• Sumoto Kunihiro

  Fukuoka Univ. Fukuoka Jpn

• Sumoto Kunihiro

  Faculty Of Pharmaceutical Sciences Fukuoka University

• Sumoto Kunihiro

  Faculty of Pharmaceutical Science, Fukuoka University

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