Synthesis and Antiviral Activities of N-Mono- and/or N,N'-Di- Carbamoyl and Acyl Derivatives of Symmetrical Diamines
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概要
- 論文の詳細を見る
N-carbamoyl and N-acyl diamine derivatives were synthesized from symmetrical diamines by their addition to iso(thio)cyanates, cleavage reaction of acid anhydride, or N-acylation by acyl chloride. (1R,2R)-1,2-Diaminocyclohexane [(1R,2R)-1], meso-1,2-diaminocyclohexane (meso-1),(1R,2R)-1,2-diphenylethylenediamine [(1R,2R)-3], or meso-1,2-diphenylethylenediamine (meso-3) were used as the starting symmetrical diamines. The target compounds synthesized herein were evaluated for antiviral activity with herpes simplex virus type 1 (HSV-1). A few derivatives of 1,2-diaminocyclohexane [(1R,2R)-7aa and cis-7b] with adamantyl group(s) showed significant antiviral activity (EC_<50>=16.0, 27.0μg/ml).
- 公益社団法人日本薬学会の論文
- 2008-07-01
著者
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Mibu N
Faculty Of Pharmaceutical Sciences Fukuoka University
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YOKOMIZO Kazumi
Faculty of Medical and Pharmaceutical Sciences, Kumamoto University
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Yokomizo K
Kumamoto Univ. Kumamoto Jpn
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Miyata Takeshi
Faculty Of Pharmaceutical Sciences Sojo University
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Mibu Nobuko
Faculty Of Pharmaceutical Sciences Fukuoka University
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Yokomizo Kazumi
Laboratory Of Pharmaceutical Microbiology Faculty Of Medical And Pharmaceutical Sciences Kumamoto Un
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Yokomizo Kazumi
Faculty Of Pharmaceutical Sciences Kumamoto University
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SUMOTO Kunihiro
Faculty of Pharmaceutical Sciences, Fukuoka University
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OISHI Marumi
Faculty of Pharmaceutical Sciences, Fukuoka University
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Oishi Marumi
Faculty Of Pharmaceutical Sciences Fukuoka University
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Sumoto K
Faculty Of Pharmaceutical Sciences Fukuoka University
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Sumoto Kunihiro
Fukuoka Univ. Fukuoka Jpn
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Sumoto Kunihiro
Faculty Of Pharmaceutical Sciences Fukuoka University
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Sumoto Kunihiro
Faculty of Pharmaceutical Science, Fukuoka University
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