Preferential Intramolecular Ring Closure of Aminoalcohols with Diethyl Carbonate to Oxazolidinones
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概要
- 論文の詳細を見る
The closure by cyclization with diethyl carbonate (EtO)_2CO from aminoalcohols 1 as starting material can lead to the oxazolidinones 2a, b and 2c, respectively. In the reaction of frans-isomer (6) and (EtO)_2CO, isolated products were also only 5-membered oxazolidinone derivative (7), containing its dehydrated derivative 8. The preferential formation of the 5-membered oxazolidinone ring system apparently indicated that this process (5-Exo-Trig ring closure) is more favorable than that of 6- or 7-membered ring derivative (3 or 9) by 6- or 7-Exo-Trig ring closure.
- 公益社団法人日本薬学会の論文
- 2007-05-01
著者
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Oishi Marumi
Faculty Of Pharmaceutical Sciences Fukuoka University
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Sumoto K
Faculty Of Pharmaceutical Sciences Fukuoka University
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Sumoto Kunihiro
Fukuoka Univ. Fukuoka Jpn
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Sumoto Kunihiro
Faculty Of Pharmaceutical Sciences Fukuoka University
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Fujisaki Fumiko
Faculty Of Pharmaceutical Sciences Fukuoka University
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Sumoto Kunihiro
Faculty of Pharmaceutical Science, Fukuoka University
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Fujisaki Fumiko
Faculty of Pharmaceutical Science, Fukuoka University
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