Molecular Symmetry and Biological Activities of New Symmetrical Tris(2-aminoethyl)amine Derivatives

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概要

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• In terms of molecular symmetry and bioactivity, new C3- and CS-symmetrical derivatives based on the tris(2-aminoethyl)amine scaffold were designed and synthesized. The synthesized compounds were evaluated for antiviral activity with herpes simplex virus type 1 (HSV-1) by a plaque reduction assay and for cytotoxic activity with Vero cells. Most of the compounds showed no significant anti-HSV-1 activity, but some of the symmetrical derivatives showed high levels of cytotoxic activitiy.

• 公益社団法人　日本薬学会の論文

著者

• YOKOMIZO Kazumi

  Faculty of Medical and Pharmaceutical Sciences, Kumamoto University

• Miyata Takeshi

  Faculty Of Pharmaceutical Sciences Sojo University

• Mibu Nobuko

  Faculty Of Pharmaceutical Sciences Fukuoka University

• Sumoto Kunihiro

  Faculty Of Pharmaceutical Sciences Fukuoka University

• Aki Hatsumi

  Faculty Of Pharmaceutical Fukuoka University

• Uchida Wataru

  Faculty of Pharmaceutical Sciences, Fukuoka University

• Takemura Satoshi

  Faculty of Pharmaceutical Sciences, Fukuoka University

• Zhou Jianrong

  Faculty of Pharmaceutical Sciences, Sojo University

• YOKOMIZO Kazumi

  Faculty of Pharmaceutical Sciences, Sojo University

• Miyata Takeshi

  Faculty of Pharmaceutical Sciences, Sojo University

• Sumoto Kunihiro

  Faculty of Pharmaceutical Science, Fukuoka University

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