Incompatibility between Propericiazine Oral Solution and Tea-Based Drink

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概要

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• Here, we studied the incompatibility between an oral solution of propericiazine (PCZ), an antipsychotic drug, and various commercially available bottled tea-based drinks. When 0.5 mL of the PCZ oral solution (10 mg/mL) was mixed with 16.5 mL of a tea-based drink (such as green tea, oolong tea, and black tea), the residual PCZ content declined to approximately 50% in some mixed solutions. After mixing with other tea-based drinks, the residual PCZ content declined to approximately 30%, while in others, it changed very little. The residual PCZ content declined immediately after mixing with tea-based drinks, but the rate remained almost unchanged for the next 24 h. Furthermore, the pH of the mixture increased to 4.5–5.1 after the oral solution of PCZ (original pH 3.8) was diluted with various tea-based drinks. Afterwards, the pH did not change for 24 h. The mixture became cloudy immediately after diluting PCZ oral solution with tea-based drinks, and the insoluble substance gradually precipitated. In order to elucidate factors responsible for the decline in the content of PCZ, a (−)-epigallocatechin gallate solution, which is a main ingredient of green tea polyphenol, was mixed with the PCZ oral solution. After mixing, the residual PCZ content declined to approximately 60–75%. On the other hand, the content of PCZ did not decline when a (−)-epigallocatechin solution was mixed with the PCZ oral solution. The results from this study demonstrated that PCZ content was reduced after dilution in tea-based drinks because of the interaction between PCZ and polyphenol with a galloyl group in tea-based drinks.

• 公益社団法人　日本薬学会の論文

著者

• IKEDA Hirohito

  Faculty of Pharmaceutical Sciences, Fukuoka University

• FUJISAWA Masao

  Department of Biotechnological Science, Kinki University

• Yukawa Miho

  Faculty Of Pharmaceutical Fukuoka University

• Aki Hatsumi

  Faculty Of Pharmaceutical Fukuoka University

• Ikeda Hirohito

  Faculty Of Pharmaceutical Fukuoka University

• Tsuji Erika

  Faculty of Pharmaceutical Sciences, Fukuoka University

• Matsubara Tomonori

  Faculty of Pharmaceutical Sciences, Fukuoka University

• Yukawa Eiji

  Faculty of Pharmaceutical Sciences, Daiichi University of Pharmacy

• Fujisawa Masao

  Department Of Biotechnological Science Kinki University

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