Royal Jelly Stimulates Bone Formation : Physiologic and Nutrigenomic Studies with Mice and Cell Lines
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概要
- 論文の詳細を見る
Royal jelly (RJ) has diverse physiological and pharmacological functions. We observed its weak estrogenic activity in the previous study. RJ stimulated the proliferation of mouse osteoblast-like MC3T3-E1 cells at 0.1 mg/ml, and the effect was blocked by the specific estrogen receptor antagonist ICI 182,780. The addition of 0.1–1.0 mg/ml RJ enhanced collagen production in culture medium. Oral administration of RJ to normal female mice for 9 weeks increased the ash content of their tibiae. DNA microarray analysis revealed significant changes in gene expression related to extracellular matrix formation when the femurs of mice fed RJ were analyzed. Quantitative reverse transcriptase-PCR (RT-PCR) confirmed up-regulation of procollagen I α1 gene expression. These data suggest that RJ as a whole or some of its individual components stimulates production of type I collagen and other activities for bone formation through action on osteoblasts.
- 2006-10-23
著者
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Abe Keiko
Agricultural And Life Sciences Dep. Of Applied Biological Chemistry
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宮田 健
熊本大学大学院医学薬学研究部薬物活性学分野
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Akao Y
Gifu International Institute Of Biotechnology
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Miyata Takeshi
Lab. Of Presymptomatic Medical Pharmacology Fac. Of Pharmaceutical Sciences Sojo Univ. Jpn
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Miyata Takeshi
Faculty Of Pharmaceutical Sciences Sojo University
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MISHIMA Satoshi
Nagaragawa Research Center, API Co., Ltd.
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Miyata T
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Kumamoto University
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Inoh Yoshikazu
Nagaragawa Research Center Api Co. Ltd.
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ISOHAMA Yoichiro
Faculty of Pharmaceutical Sciences, Kumamoto University
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Araki Yoko
Nagaragawa Res. Center Api Co. Ltd.
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Araki Yoko
Nagaragawa Research Center Api Co. Ltd.
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Isohama Yoichiro
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Kumamoto University
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Isohama Yoichiro
Faculty Of Pharmaceutical Science Kumamoto University
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ABE Keiko
Graduate School of Agricultural and Life Sciences, the University of Tokyo
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Okada Shinji
Graduate School Of Agricultural And Life Sciences Department Of Applied Biological Chemistry The Uni
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Matsumoto Ichiro
Graduate School Of Agricultural And Life Sciences The Univ. Of Tokyo
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Mishima Satoshi
Nagaragawa Res. Center Api Co. Ltd.
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Mishima Satoshi
Nagaragawa Research Center Api Co. Ltd.
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Araki Yoko
Nagara Res. Center Api Co. Ltd.
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NARITA Yukio
Nagaragawa Research Center, API Co., Ltd.
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NOMURA Johji
Faculty of Pharmaceutical Science, Kumamoto University
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OHTA Shozo
Nagaragawa Research Center, API Co., Ltd.
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SUZUKI Kazu-Michi
Nagaragawa Research Center, API Co., Ltd.
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Abe Keiko
Graduate School Of Agricultural And Life Sciences Univ. Of Tokyo
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Ohta Shozo
Nagaragawa Research Center Api Co. Ltd.
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Nomura Johji
Faculty Of Pharmaceutical Science Kumamoto University
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Narita Yukio
Nagaragawa Research Center Api Co. Ltd.
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Suzuki Kazumichi
Nagaragawa Research Center Api Co. Ltd.
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Abe Keiko
Graduate School Of Agricultural And Life Sciences The University Of Tokyo
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Okada Shinji
Department Of Applied Biological Chemistry Graduate School Of Agricultural And Life Sciences The Uni
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Abe Keiko
Department Of Applied Biological Chemistry Graduate School Of Agricultural And Life Sciences The Uni
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Matsumoto Ichiro
Dep. Of Applied Biological Chemistry Graduate School Of Agricultural And Life Sciences The Univ. Of
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Abe Keiko
Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo
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