Two Related Cinnamic Acid Derivatives from Brazilian Honey Bee Propolis, Baccharin and Drupanin, Induce Growth Inhibition in Allografted Sarcoma S-180 in Mice(Pharmacognosy)

スポンサーリンク

概要

• 論文の詳細を見る

• Honey bee propolis is rich in cinnamic acid derivatives. Baccharin and drupanin from Brazilian honey bee propolis are cinnamic acid derivatives that contain prenyl moieties. We previously isolated these two compounds and demonstrated that they induce an apoptotic event in several tumor cell lines. In this study, we examined the tumoricidal activity of baccharin and drupanin in mice allografted with sarcoma S-180 and also studied the genotoxic effects on normal splenocytes using the alkaline single cell gel (comet) assay. We found that both baccharin and drupanin effectively suppressed growth of the tumor. Furthermore, these compounds induced a significant genotoxic effect on the tumor cells in comparison with normal splenocytes. Thus, baccharin and drupanin are potent tumor suppressive components of honeybee propolis.

• 公益社団法人日本薬学会の論文
• 2005-06-01

著者

• Nozawa Yoshinori

  Gifu International Institute of Biotechnology

• AKAO Yukihiro

  Gifu International Institute of Biotechnology

• Akao Y

  Gifu International Institute Of Biotechnology

• Nozawa Y

  Gifu International Institute Of Biotechnology

• Araki Yoko

  Nagaragawa Res. Center Api Co. Ltd.

• Araki Yoko

  Nagaragawa Research Center Api Co. Ltd.

• ARAKI Yoko

  API Company Limited Research Institute

• MISHIMA Satoshi

  API Company Limited Research Institute

• ONO Yosuke

  API Co. Ltd., R&D

• Mishima Satoshi

  Nagaragawa Research Center Api Co. Ltd.

• Mishima Satoshi

  Api Co. Ltd. Nagaragawa Research Center

• Ono Yosuke

  Api Co. Ltd. R&d

関連論文

• Effects of Sesquiterpene Lactones on Melanogenesis in Mouse B16 Melanoma Cells(Biopharmacy)
• Mutated RAS Induced PLD1 Gene Expression through Increased Sp1 Trascription Factor
• Downregulation of microRNAs-143 and -145 in B-cell malignancies
• let-7 MicroRNA Functions as a Potential Growth Suppressor in Human Colon Cancer Cells(Molecular and Cell Biology)
• Inhibitory Effects of Whisky Congeners on Melanogenesis in Mouse B16 Melanoma Cells
• Magnolol-Induced Apoptosis Is Mediated via the Intrinsic Pathway with Release of AIF from Mitochondria in U937 Cells(Molecular and Cell Biology)
• P2-19 Phosphorylation by MAP kinase of a Multi-Domain Adaptor Protein, Vinexin, in Neurons
• Possible interaction of a Rho effector, Rhotekin, with a PDZ-protein, PIST, at synapses of hippocampal neurons
• Association of candidate gene polymorphisms with chronic kidney disease in Japanese individuals with hypertension
• Pepsin-Digested Bovine Lactoferrin Induces Apoptotic Cell Death With JNK/SAPK Activation in Oral Cancer Cells
• Involvement of phosphatidylcholine hydrolysis by phospholipase C in prostaglandin F2α-induced 1, 2-diacylglycerol formation in osteoblast-like MC3T3-E1 cells
• Antitumor effect of arsenic trioxide in murine xenograft model
• A Potent Apoptosis-Inducing Activity of a Sesquiterpene Lactone, Arucanolide, in HL60 Cells : a Crucial Role of Apoptosis-Inducing Factor
• Growth Inhibition of Stilbenoids in Welwitschiaceae and Gnetaceae through Induction of Apoptosis in Human Leukemia HL60 Cells(Molecular and Cell Biology)
• Vaticanol C-Induced Cell Death Is Associated with Inhibition of Pro-Survival Signaling in HL60 Human Leukemia Cell Line
• Antihypertensive Effects of Flavonoids Isolated from Brazilian Green Propolis in Spontaneously Hypertensive Rats
• Antihypertensive Effect of Peptides from Royal Jelly in Spontaneously Hypertensive Rats(Pharmacognosy)
• Cell Growth Inhibitory Effect of Cinnamic Acid Derivatives from Propolis on Human Tumor Cell Lines
• Royal Jelly Stimulates Bone Formation : Physiologic and Nutrigenomic Studies with Mice and Cell Lines
• 1,1-Diphenyl-2-picrylhydrazyl Radical Scavenging Activity of Bee Products and Their Constituents Determined by ESR
• Cytotoxic Benzophenone Derivatives from Garcinia Species Display a Strong Apoptosis-Inducing Effect against Human Leukemia Cell Lines
• N-trans-Feruloyltyramine as a Melanin Biosynthesis Inhibitor(Medicinal Chemistry)
• Stimulation of Melanogenesis by the Citrus Flavonoid Naringenin in Mouse B16 Melanoma Cells
• Two Related Cinnamic Acid Derivatives from Brazilian Honey Bee Propolis, Baccharin and Drupanin, Induce Growth Inhibition in Allografted Sarcoma S-180 in Mice(Pharmacognosy)
• Inhibitory Effects of Resveratrol Derivatives from Dipterocarpaceae Plants on Tyrosinase Activity(Biochemistry & Molecular Biology)
• Gnetol as a Potent Tyrosinase Inhibitor from Genus Gnetum(Biochemistry & Molecular Biology)
• Vaticanol C, a Novel Resveratrol Tetramer, Inhibits Cell Growth through Induction of Apoptosis in Colon Cancer Cell Lines
• Antioxidant and Immuno-Enhancing Effects of Echinacea purpurea(Pharmacology)
• Lig-8, a Bioactive Lignophenol Derivative From Bamboo Lignin, Protects Against Neuronal Damage In Vitro and In Vivo
• Effects of Theaflavins on Melanin Biosynthesis in Mouse B16 Melanoma Cells
• Inhibitory Effects of Whisky Congeners on Melanogenesis in Mouse B16 Melanoma Cells
• Estrogenic effects of royal jelly(Chemical & Pharmacological study)
• テトラヒメナ細胞死における細胞解体過程を誘導するパルス熱ショック法
• Agarwood Induced Laxative Effects via Acetylcholine Receptors on Loperamide-Induced Constipation in Mice
• Effects of Long-Term Administration of Royal Jelly on Pituitary Weight and Gene Expression in Middle-Aged Female Rats
• A Thematic Series on Lipid Signaling : Prologue
• Role of Oxidative Stress in Retinal Photoreceptor Cell Death in N-Methyl-N-nitrosourea-Treated Mice
• Inhibitory Effects of Flavonoid Glycosides Isolated from the Peel of Japanese Persimmon (Diospyros kaki ‘Fuyu’) on Melanin Biosynthesis
• NovQ is a prenyltransferase capable of catalyzing, the addition of a dimethylallyl group to both phenylpropanoids and flavonoids
• Identification of Phenolic Compounds in Aquilaria crassna Leaves Via Liquid Chromatography-Electrospray Ionization Mass Spectroscopy
• Antioxidant Activity and Phenolic Constituents of Red Propolis from Shandong, China
• Transcriptional regulation of neutral sphingomyelinase 2 in all-trans retinoic acid-treated human breast cancer cell line, MCF-7

もっと見る 閉じる

スポンサーリンク