Cytotoxic Benzophenone Derivatives from Garcinia Species Display a Strong Apoptosis-Inducing Effect against Human Leukemia Cell Lines

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概要

• 論文の詳細を見る

• We examined the in vitro effects of the benzophenone derivatives garcinol, isogarcinol, and xanthochymol on cell growth in four human leukemia cell lines. All of the compounds exhibited significant growth suppression due to apoptosis mediated by the activation of caspase-3. A loss of mitochondria) membrane potential was found in garcinol- and isogarcinol-induced apoptosis, but not in xanthochymol-induced apoptosis. The growth inhibitory effects of isogarcinol and xanthochymol were more potent than that of garcinol, which is a well- known cytotoxic benzophenone derivative.

• 公益社団法人日本薬学会の論文
• 2003-04-01

著者

• IINUMA Munekazu

  Gifu Pharmaceutical University

• TANAKA Toshiyuki

  Gifu Prefectural Institute of Health and Environmental Sciences

• Iinuma Munekazu

  Dep. Of Bioactive Molecules Pharmacognosy Gifu Pharmaceutical Univ.

• Iinuma M

  Gifu Pharmaceutical University

• Iinuma Munekazu

  岐阜薬科大学

• Iinuma M

  城西大学薬学部

• Tanaka Toshiyuki

  Gifu Pharmaceutical Univ.

• Nozawa Yoshinori

  Gifu International Institute of Biotechnology

• Tanaka T

  Osaka Univ. Osaka Jpn

• Ohguchi Kenji

  Gifu International Institute of Biotechnology

• AKAO Yukihiro

  Gifu International Institute of Biotechnology

• Ito Tetsuro

  Gifu Prefectural Institute of Health and Environmental Sciences

• Ito Tetsuro

  Laboratory of Pharmacognosy, Gifu Pharmaceutical University

• Kobayashi E

  Pharmaceutical Research Institute Kyowa Hakko Kogyo Company Ltd.

• Ito T

  Dep. Of Bioactive Molecules Pharmacognosy Gifu Pharmaceutical Univ.

• Akao Y

  Gifu International Institute Of Biotechnology

• Nozawa Y

  Gifu International Institute Of Biotechnology

• MATSUMOTO Kenji

  Gifu International Institute of Biotechnology

• Tanaka Toshiyuki

  Gifu Prefectrual Inst. Health And Environmental Sci. Gifu Jpn

• Iinuma Munekazu

  Gifu Prefectural Institute Of Health And Environment

• Araki Yoko

  Nagaragawa Res. Center Api Co. Ltd.

• Araki Yoko

  Nagaragawa Research Center Api Co. Ltd.

• Kobayashi E

  Gifu Pharmaceutical University : Gifu Prefectural Institute Of Health And Environmental Sciences

• MATUMOTO kenji

  Gifu Inlet-national Institute of Biotechnology

• KOBAYASHI Emi

  Gifu Pharmaceutical University

• OUGUCHI Kenji

  Gifu Inlet-national Institute of Biotechnology

• Matsumoto K

  Gifu International Institute Of Biotechnology

• Matsumoto Keiji

  Department Of Orthopaedic Surgery Shiga University Of Medical Science

• Tanaka Toshiyuki

  Gifu Pharmaceutical University

• Ito Tetsuro

  Department Of Bioactive Molecutes Pharmacognosy Gifu Pharmaceutical University

• Ito T

  Gifu Prefectrual Inst. Health And Environmental Sci. Kakamigahara Jpn

• Iinuma Munekazu

  Gifu Pharmaceutical Univ.gifu Jpn

• Matsumoto K

  Central Research Laboratory Hitachi Ltd.

• Tanaka Terumichi

  Division Of Bioscience And Biotechnology Department Of Ecological Engineering Toyohashi University O

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