Inhibitory Activity of Plant Stilbene Oligomers against DNA Topoisomerase II(Pharmacognosy)
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概要
- 論文の詳細を見る
The inhibitory activity of 40 stilbene oligomers isolated from six plant species against topoisomerase II was evaluated, of which nine compounds showed a potent inhibitory effect, stronger than daunorubicin, a topoisomerase II inhibitor, used as an anti-cancer drug. The specificity of active stilbene oligomers on topoisomerase II was assessed by their effect on DNA restriction enzyme. In particular, specific inhibitory activity was observed in α-viniferin 13-O-β-glucopryranoside (2) and hemsleyanol C (13).
- 公益社団法人日本薬学会の論文
- 2006-07-01
著者
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Iinuma Munekazu
Dep. Of Bioactive Molecules Pharmacognosy Gifu Pharmaceutical Univ.
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Iinuma M
Gifu Pharmaceutical University
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Iinuma Munekazu
岐阜薬科大学
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Iinuma M
城西大学薬学部
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IINUMA Munekazu
Department of Pharmacognosy, Gifu Pharmaceutical University
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Ito Tetsuro
Gifu Prefectural Institute of Health and Environmental Sciences
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Ito Tetsuro
Laboratory of Pharmacognosy, Gifu Pharmaceutical University
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NOZAKI Hiroshi
Department of Biological Chemistry, Faculty of Science, Okayama University of Science
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Yamada Masayuki
Department Of Polymer Chemistry Tokyo Institute Of Technology
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Naganawa H
Department Of Biological Chemistry Faculty Of Science Okayama University Of Science
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Nozaki H
Meiji Milk Products Co. Ltd. 26-11 Midori 1 Chime
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Iinuma Munekazu
Gifu Prefectural Institute Of Health And Environment
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Iinuma Munekazu
Gifu Prefectural Institute Of Health And Environmental Sciences
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YAMADA Masashi
Meiji Dairies Corporation
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IKEDA Shogo
Department of Biochemistry, Cancer Institute, Okayama University Medical School
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Hayashi Ken-ichiro
Department of Agricultural Chemistry, Faculty of Agriculture, University of Osaka Prefecture
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Yamada M
Division Of Protein Biosynthesis Institute For Protein Research Osaka University
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Hayashi Ken-ichiro
Department Of Biological Chemistry Faculty Of Science Okayama University Of Science
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Ikeda Shougo
Department Of Biological Chemistry Faculty Of Science Okayama University Of Science
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Ikeda Shogo
Department Of Biochemistry Cancer Institute Okayama University Medical School
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Tsutsui Ken
Graduate School Of Medicine Dentistry And Pharmaceutical Science Okayama University
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Yamada Masayoshi
Meiji Dairies Corporation
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TSUTSUI Kimiko
Graduate School of Medicine, Dentistry and Pharmaceutical Science, Okayama University
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Nozaki Hiroshi
Department Of Biochemistry Faculty Of Science Okayama University Of Science
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Ito Tetsuro
Department Of Bioactive Molecutes Pharmacognosy Gifu Pharmaceutical University
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Iinuma Munekazu
Department Of Bioactive Molecutes Pharmacognosy Gifu Pharmaceutical University
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Tsutsui Ken
Graduate School Of Interdisciplinary New Science Toyo University
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Nozaki Hiroshi
Department Of Biochemistry Faculty Of Science
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Nozaki H
Department Of Biological Chemistry Faculty Of Science Okayama University Of Science
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Yamada Masashi
Department Of Biological Chemistry Faculty Of Science Okayama University Of Science
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IINUMA Munekazu
Department of Bioactive Molecules, Pharmacognosy, Gifu Pharmaceutical University
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IKEDA Shogo
Department of Applied Biochemistry, Faculty of Applied Biological Science, Hiroshima University
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