Cell Growth Inhibition by Membrane-Active Components in Brownish Scale of Onion
スポンサーリンク
概要
- 論文の詳細を見る
The growth-inhibitory effects of the brownish scale components of onion on tumor cells were studied with relating to their membrane activity. Quercetin, quercetin-4'-O-glucoside and two isomeric quercetin dimers (10μM for each) isolated from the scale reduced the fluidity of tumor cell model membranes consisting of phospholipids and cholesterol more significantly than that of normal cell model membranes. In flavonoidal components, the membrane activity was greatest in the order of dimers, aglycone and glucoside. Quercetin and its dimers intensively acted on the membrane center rather than the membrane surface, while quercetin-4'-O-glucoside was relatively effective on the hydrophilic regions of membranes. Membrane-active flavonoids inhibited the growth of mouse myeloma cells at 10-100μM with the same rank of order of potency as they rigidified liposomal membranes. Quercetin and its dimers rigidified cell membranes by acting on the hydrophobic inner regions simultaneously with inhibiting the cell growth, but not quercetin-4'-O-glucoside. Flavonoidal components in the brownish scale of onion have the potent anti-proliferative activity associated with the structure-specific rigidification of cell membranes, which is induced by the interaction with membrane lipid bilayers.
- 公益社団法人日本薬学会の論文
- 2006-10-01
著者
-
IINUMA Munekazu
Gifu Pharmaceutical University
-
田中 利男
帝人株式会社 医薬岩国製造所
-
Hatano Tsutomu
エジプト
-
Hatano Tsutomu
Division Of Pharmaceutical Sciences Okayama University Graduate School Of Medicine Dentistry And Pha
-
Hatano Tsutomu
Okayama Univ. Okayama Jpn
-
Hatano Tsutomu
岡山大学 医歯薬学総合研究科分子微生物学
-
FURUSAWA Miyuki
Gifu Prefectural Institute of Health and Environmental Sciences
-
TANAKA Toshiyuki
Gifu Prefectural Institute of Health and Environmental Sciences
-
Iinuma Munekazu
Dep. Of Bioactive Molecules Pharmacognosy Gifu Pharmaceutical Univ.
-
Iinuma M
Gifu Pharmaceutical University
-
Iinuma Munekazu
岐阜薬科大学
-
Iinuma M
城西大学薬学部
-
Tanaka Toshiyuki
Gifu Pharmaceutical Univ.
-
Tanaka T
Kvushu Univ. Fukuoka Jpn
-
Tanaka T
Osaka Univ. Osaka Jpn
-
Okano M
Kitasato Univ. Sagamihara Jpn
-
土屋 博紀
Asahi Univ. School Of Dentistry Gifu Jpn
-
大村 三男
Fruit Tree Research Station
-
Ito Tetsuro
Gifu Prefectural Institute of Health and Environmental Sciences
-
Ito Tetsuro
Laboratory of Pharmacognosy, Gifu Pharmaceutical University
-
Oyama Masayoshi
Laboratory of Pharmacognosy, Gifu Pharmaceutical University
-
Ito T
Dep. Of Bioactive Molecules Pharmacognosy Gifu Pharmaceutical Univ.
-
土屋 博紀
朝日大学歯学部口腔細菌学講座
-
Omura M
Okitsu Branch Fruit Tree Research Station Ministry Of Agriculture Forestry And Fisheries
-
Omura Mitsuo
Faculty Of Pharmacy Meijo University
-
Ohtani Mikinobu
Department Of Urology Instiute Of Clinical Medicine University Of Tsukuba
-
Tanaka Toshiyuki
Gifu Prefectrual Inst. Health And Environmental Sci. Gifu Jpn
-
OYAMA Masayoshi
Gifu Pharmaceutical University
-
Iinuma Munekazu
Gifu Prefectural Institute Of Health And Environment
-
Iinuma Munekazu
Gifu Prefectural Institute Of Health And Environmental Sciences
-
Tsuchiya Hironori
Asahi University School of Dentistry
-
Nagayama Motohiko
Asahi University School of Dentistry
-
Nagayama Motohiko
Department of Dental Basic Education, Asahi University School of Dentistry
-
Takeuchi Hiroshi
Asahi University School of Dentistry
-
Furasawa M
Gifu Prefectural Institute Of Health And Environmental Sciences
-
Onozawa Mizuki
Cancer Prevenition Division National Cancer Center Research Instiute
-
波多野 力
岡山大学・院医歯薬・創薬
-
Ohyama M
Cancer Prevenition Division National Cancer Center Research Instiute
-
Tanaka Toshiyuki
Gifu Pharmaceutical University
-
田中 徹明
Osaka Univ. Osaka Jpn
-
Ito Tetsuro
Department Of Bioactive Molecutes Pharmacognosy Gifu Pharmaceutical University
-
Nagayama Motohiko
Department Of Dental Basic Education Asahi University School Of Dentistry
-
Nagayama Motohiko
Asahi Univ. School Of Dentistry Gifu Jpn
-
Ito T
Gifu Prefectrual Inst. Health And Environmental Sci. Kakamigahara Jpn
-
Iinuma Munekazu
Gifu Pharmaceutical Univ.gifu Jpn
-
Tanaka Terumichi
Division Of Bioscience And Biotechnology Department Of Ecological Engineering Toyohashi University O
関連論文
- Effects of Sesquiterpene Lactones on Melanogenesis in Mouse B16 Melanoma Cells(Biopharmacy)
- Hydroxychavicol : a potent xanthine oxidase inhibitor obtained from the leaves of betel, Piper betle
- Histamine Release Inhibitory Activity of Piper nigrum Leaf(Pharmacognosy)
- Synergistic Effect of Kaempferol Glycosides Purified from Laurus nobilis and Fluoroquinolones on Methicillin-Resistant Staphylococcus aureus(Microbiology)
- スギヒラタケに含まれる特徴的な長鎖脂肪酸について
- β-carbolines の毛髪分析
- 66 ツバキおよび近縁植物の抗HIV作用を有するタンニン(ポスター発表の部)
- 29 大環状構造を有する抗腫瘍性加水分解性タンニンオリゴマー(ポスター発表の部)
- Anti-methicillin Resistant Staphylococcus aureus (MRSA) Compounds Isolated from Laurus nobilis(Microbiology)
- Effect of Polygala tenuifolia Root Extract on Scopolamine-Induced Impairment of Rat Spatial Cognition in an Eight-Arm Radial Maze Task(Pharmacology)
- B-15 阿仙薬のポリフェノール成分による品質評価(薬物代謝・天然物化学,一般演題口演,第24回和漢医薬学会大会 和漢薬の複雑さ-経験知と科学知-)
- 阿仙薬のポリフェノール性成分による品質評価
- Antimicrobial Activity of Oleanolic Acid from Salvia officinalis and Related Compounds on Vancomycin-Resistant Enterococci (VRE)(Microbiology)
- Cowaniin, a C-Glucosidic Ellagitannin Dimer Linked through Catechin from Cowania mexicana
- Potentiation of Antimicrobial Activity of Aminoglycosides by Carnosol from Salvia officinalis(Microbiology)
- Revised Structures of Gambiriins A1, A2, B1, and B2, Chalcane-Flavan Dimers from Gambir (Uncaria gambir Extract)
- Effects of Chlorogenic Acid and Its Metabolites on Spontaneous Locomotor Activity in Mice
- P-17 阿仙薬に含まれるポリフェノール成分(ポスター発表の部)
- Conjugated Ketonic Fatty Acids from Pleurocybella porrigens
- P-236 CONJUGATED LONG-CHAIN FATTY ACIDS OF PLEUROCYBELLA PORRIGENS
- P-172 ANTIFUNGAL CONSTITUENTS FROM SANTALUM ALBUM OF INDIAN ORIGIN
- Urinary Excretion of Anthocyanins in Humans after Cranberry Juice Ingestion
- Polyphenolic Constituent Structures of Zanthoxylum piperitum Fruit and the Antibacterial Effects of Its Polymeric Procyanidin on Methicillin-Resistant Staphylococcus aureus
- 木本性植物の組織培養によるタンニン生産と生合成
- Synergistic Effect of [10]-Gingerol and Aminoglycosides against Vancomycin-Resistant Enterococci (VRE)(Microbiology)
- Water-Soluble Complexes Formed by Natural Polyphenols and Bovine Serum Albumin : Evidence from Gel Electrophoresis
- Interaction of the Aryl Hydrocarbon Receptor with Several Constituents from Spinach and Komatsuna Extracts Determined Using in Vitro Bioassay
- Cypellogins A, B and C, Acylated Flavonol Glycosides from Eucalyptus cypellocarpa
- Remarkable Synergies between Baicalein and Tetracycline, and Baicalein and β-Lactams against Methicillin-Resistant Staphylococcus aureus
- Two New Analogues of Trijugin-Type Limonoids from the Leaves of Sandoricum koetjape
- Chemical Constituents of Artemisia herba-alba Asso
- 天然ナノ分子タンニン : その構造と機能
- Antibacterial Activity of Hydrolyzable Tannins Derived from Medicinal Plants against Helicobacter pylori
- K-083(30) 茶葉ポリフェノールの血清アルブミンとの複合体形成
- メチシリン耐性黄色ブドウ球菌(MRSA)に対する山椒中の作用物質
- ビワ葉の抗腫瘍性成分
- Hydrolysable Tannin Production in Oenothera tetraptera Shoot Tissue Culture
- 天然由来抗MRSA物質の探索
- E-5 大棗のポリフェノール成分とそのメチシリン耐性黄色ブドウ球菌に対する抗生物質耐性抑制作用
- Proanthocyanidins and Related Compounds:Antileishmanial Activity and Modulatory Effects on Nitric Oxide and Tumor Necrosis Factor-α-Release in the Murine Macrophage-Like Cell Line RAW 264.7
- Tannins and Related Polyphenols,HIV Reverse Transcriptase Inhibitors, from Rosa woodsii
- P-87 山椒のMRSAに対する抗菌作用成分
- Phenolic Constituents of Licorice. VIII. Structures of Glicophenone and Glicoisoflavanone, and Effects of Licorice Phenolics on Methicillin-Resistant Staphylococcus aureus
- P-41 サンマ由来変異原2-chloro-4-methylthiobutanoic acidと2'-デオキシグアノシンとの反応によって生じる付加体の同定(ポスター(1))
- P1-015 2-chloro-4-methylthiobutanoic acidとデオキシグアノシンの反応により形成するDNA付加体の解析(DNA損傷)
- 生体膜との相互作用と植物性食品の機能性
- 炎症組織における局所麻酔効果減弱の仮説的機序--局所麻酔薬の膜流動性作用に及ぼすpHとPeroxynitriteの影響 (第25回生体膜と薬物の相互作用シンポジウム--ダイナミックインターフェイスとしての生体膜 講演要旨集)
- 機能性食品活性成分と生体膜の相互作用--Allium属植物に含まれるフラボノイドならびに硫化アリルによる膜流動性変化 (第25回生体膜と薬物の相互作用シンポジウム--ダイナミックインターフェイスとしての生体膜 講演要旨集)
- Flavonol Glycosides in Leaves of Two Diospyros Species
- II-C-9 山茱萸のタンニン関連成分
- Studies on Inhibition Mechanism of Autoxidation by Tannins and Flavonoids. V. Radical-Scavenging Effects of Tannins and Related Polyphenols on 1,1-Diphenyl-2-picrylhydrazyl Radical
- New isoflavone glycosides from Iris spuria L. (Calizona) cultivated in Egypt
- 構造ならびに液性に依存した局所麻酔薬の膜流動化作用と逆相分配HPLC保持能 (第26回 生体膜と薬物の相互作用シンポジウム 講演要旨集)
- 新規β1選択的遮断薬の膜作用の可能性 (第26回 生体膜と薬物の相互作用シンポジウム 講演要旨集)
- P-448 STRUCTURES OF STILBENE OLIGOMERS IN DIPTEROCARPACEAEOUS PLANTS
- New resveratrol oligomers in the stem bark of Vatica pauciflora
- 局所麻酔薬の立体構造による膜作用の相違と膜脂質組成の関与
- 辛味物質カプサイシンの非神経性二相性膜作用
- Beta-Carboline Alkaloids in Crude Drugs
- Effects of 70% Methanol Extract from Evodiae Fructus(Fruit of Evodia rutaecarpa var.bodinieri)and Its Alkaloidal Compnents on Blood Circulation
- イソカルバサイクリンメチルエステル含有 O/W エマルジョン製剤 TTC-909 の体内動態 (第4報) 単回静脈内投与後のイヌにおける血中濃度, 排泄および代謝
- イソカルバサイクリンメチルエステル含有 O/W エマルジョン製剤 TTC-909 の体内動態 (第2報) ラットにおける代謝
- Melanogenesis Stimulation in Murine B16 Melanoma Cells by Kava (Piper methysticum) Rhizome Extract and Kavalactones(Pharmacognosy)
- Antibacterial Activity of Stilbene Oligomers against Vancomycin-Resistant Enterococci (VRE) and Methicillin-Resistant Staphylococcus aureus (MRSA) and Their Synergism with Antibiotics
- A Monoterpene Glucoside and Three Megastigmane Glycosides from Juniperus communis var. depressa
- Three New Trimeric Stilbenes from Gnetum gnemon
- Stilbene Oligomers in Roots of Sophora moorcroftiana
- Stilbene Derivatives from Two Species of Gnetaceae
- Inhibitory Effect of Plant Extracts on Production of Verotoxin by Enterohemorrhagic Escherichia coil O157 : H7
- Stilbenoids in Lianas of Gnetum parvifolium
- Testosterone 5α-Reductase Inhibitory Active Constituents of Piper nigrum Leaf(Pharmacognosy)
- Resveratrol Tetramers with a C_6-C_3 or a C_1 Unit from Upuna borneensis
- Resveratrol Oligomers and Their O-Glucosides from Cotylelobium lanceolatum
- A New and Known Cytotoxic Aryltetralin-Type Lignans from Stems of Bursera graveolens
- Resveratrol Derivatives from Upuna borneensis
- Three New Trimeric Stilbenes from Gnetum gnemon.
- Six Flavonostilbenes from Gnetum africanum and Gnetum gnemon
- Inhibition of Preadipocyte Differentiation by Germacranolides from Calea urticifolia in 3T3-L1 Cells
- Antioxidant Activity of Hydroxyflavonoids
- Antiproliferative Effects Associated with Membrane Lipid Interaction of Green Tea Catechins
- Cell Growth Inhibition by Membrane-Active Components in Brownish Scale of Onion
- Growth Inhibition of Stilbenoids in Welwitschiaceae and Gnetaceae through Induction of Apoptosis in Human Leukemia HL60 Cells(Molecular and Cell Biology)
- Stilbenoids with One Epoxy Group from Cotylelobium lanceolatum
- Vaticanol C-Induced Cell Death Is Associated with Inhibition of Pro-Survival Signaling in HL60 Human Leukemia Cell Line
- Stilbenoids from Leaves of Upuna borneensis
- Antibacterial Activity of Extracts Prepared from Tropical and Subtropical Plants on Methicillin-Resistant Staphylococcus aureus
- Allergy-Preventive Effects of the Flowers of Impatiens textori
- Allergy-Preventive Flavonoids from Xanthorrhoea hastilis
- Cytotoxic Benzophenone Derivatives from Garcinia Species Display a Strong Apoptosis-Inducing Effect against Human Leukemia Cell Lines
- Anti-Platelet and Membrane-Rigidifying Flavonoids in Brownish Scale of Onion
- Inhibitory Effects of Resveratrol Derivatives from Dipterocarpaceae Plants on Tyrosinase Activity(Biochemistry & Molecular Biology)
- Gnetol as a Potent Tyrosinase Inhibitor from Genus Gnetum(Biochemistry & Molecular Biology)
- Vaticanol C, a Novel Resveratrol Tetramer, Inhibits Cell Growth through Induction of Apoptosis in Colon Cancer Cell Lines
- Antianaphylactic and Antipruritic Effects of the Flowers of Impatiens textori MIQ.(Pharmacognosy)
- Effects on Blood Pressure Decrease in Response to PAF of Impatiens textori MIQ.(Pharmacognosy)
- First Synthesis of Subelliptenone F, an Inhibitor of Topoisomerase II
- Hopeafuran and a C-Glucosyl Resveratrol Isolated from Stem Wood of Hopea utilis
- Stilbene Oligomers in Roots of Sophora moorcroftiana
- Inhibitory Effects of Flavonoid Glycosides Isolated from the Peel of Japanese Persimmon (Diospyros kaki ‘Fuyu’) on Melanin Biosynthesis
- Characterization of a Glycyrrhizin-Deficient Strain of Glycyrrhiza uralensis