Interaction of the Aryl Hydrocarbon Receptor with Several Constituents from Spinach and Komatsuna Extracts Determined Using in Vitro Bioassay
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概要
- 論文の詳細を見る
As a part of our study to clarify the interaction of food ingredients with the aryl hydrocarbon receptor (AhR), we studied the interaction of 10 constituents (phytol, p-coumaric acid, 5 flavonol glycosides, adenosine, guanosine and uridine), isolated from aqueous alcohol extracts of spinach and komatsuna, with the AhR by applying the AhR-based bioassay for dioxins, the Ah-Immunoassay and the AhR-dependent luciferase reporter gene assay. Among them, flavonol glycosides and phytol had slight inhibitory effects on AhR activation by 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD) at high concentrations, however the effects were not comparable with those produced by kaempferol, regarded as one of the main antagonists of AhR. Also, flavonol glycosides showed weak luciferase inductions at high concentrations.
- 社団法人日本薬学会の論文
- 2005-12-01
著者
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伊東 秀之
岡山大学大学院医歯薬学総合研究科創薬生命科学専攻
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吉田 隆志
Department Of Pharmacognosy College Of Pharmaceutical Sciences Matsuyama University
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波多野 力
Department Of Pharmacognosy Graduate School Of Medicine Dentistry And Pharmaceutical Sciences Okayam
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SASAKI Kumiko
National Institute of Health Sciences
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YOSHIDA Takashi
Faculty of Pharmaceutical Sciences, Matsuyama University
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Amakura Yoshiaki
Division of Foods, National Institute of Health Sciences
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Tsutsumi Tomoaki
Division of Foods, National Institute of Health Sciences
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Sasaki Kumiko
Division of Foods, National Institute of Health Sciences
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Nakamura Masafumi
Hiyoshi Corporation
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Ito Hideyuki
Faculty of Pharmaceutical Sciences, Okayama University
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Hatano Tsutomu
Faculty of Pharmaceutical Sciences, Okayama University
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Maitani Tamio
Division of Foods, National Institute of Health Sciences
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Hatano Tsutomu
エジプト
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Hatano Tsutomu
Division Of Pharmaceutical Sciences Okayama University Graduate School Of Medicine Dentistry And Pha
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Hatano Tsutomu
Okayama Univ. Okayama Jpn
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Hatano Tsutomu
岡山大学 医歯薬学総合研究科分子微生物学
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吉田 哲也
広島大学医学部
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Tsuchiya T
Department Of Molecular Microbiology Graduate School Of Medicine Dentistry And Pharmaceutical Scienc
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Tsuchiya Tomofusa
岡山大学 分子微生物学
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Sasaki K
Division Of Foods National Institute Of Health Sciences
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土屋 博紀
Asahi Univ. School Of Dentistry Gifu Jpn
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Nakamura M
Hiyoshi Corporation
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土屋 博紀
朝日大学歯学部口腔細菌学講座
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Ito Hideyuki
Department Of Pharmacognosy Okayama University Graduate School Of Medicine Dentistry And Pharmaceuti
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Hatano Tsutomu
Department Of Pharmacognosy Okayama University Graduate School Of Medicine Dentistry And Pharmaceuti
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Maitani T
Division Of Foods National Institute Of Health Sciences
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TSUTSUMI Tomoaki
National Institute of Health Sciences
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Yoshida T
Hokuriku Seiyaku Co. Ltd. Fukui Jpn
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Yoshida T
Department Of Microbiology Hiroshima University School Of Medicine
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Amakura Yoshiaki
Department Of Pharmacognosy College Of Pharmaceutical Sciences Matsuyama University
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Yoshida T
College Of Pharmaceutical Sciences Matsuyama University
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Takagi Miyuki
Faculty Of Pharmacy Chiba Institute Of Science
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Machiguchi Takahisa
Faculty Of Science Saitama University
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Maitani Tamio
Division Of Foods National Institute Of Health Sciences
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吉田 隆志
College Of Pharmaceutical Sciences Matsuyama University
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Yoshida Takuji
Showa Pharmaceutical University
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Hatano Tsutomu
Faculty Of Pharmaceutical Sciences Okayama University
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米谷 民雄
Division Of Foods National Institute Of Health Sciences
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Yoshida Takashi
Faculty Of Agriculture Kyusyu University
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波多野 力
岡山大学・院医歯薬・創薬
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Ito Hideyuki
Faculty Of Pharmaceutical Sciences Okayama University
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Ito Hideyuki
Department Of Pharmacognosy Pharmaceutical Sciences Okayama University Graduate School Of Medicine D
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Tanabe Tomotaka
College Of Pharmaceutical Sciences Matsuyama University
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Ito Hideyuki
Faculty Of Applied Biological Sciences Gifu University
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Yoshida Takashi
Faculty Of Agriculture And Life Science Hirosaki University
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Nakamura M
Faculty Of Pharmaceutical Sciences Fukuoka University
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