Polyphenolic Constituent Structures of Zanthoxylum piperitum Fruit and the Antibacterial Effects of Its Polymeric Procyanidin on Methicillin-Resistant Staphylococcus aureus
スポンサーリンク
概要
- 論文の詳細を見る
Zanthoxylum piperitum (Rutaceae) is used as a spice and a natural medicine in Japan. Our study found that ZP-CT-A, a polymeric proanthocyanidin purified from the fruit of this species, noticeably decreased the minimum inhibitory concentrations of β-lactam antibiotics for methicillin-resistant Staphylococcus aureus (MRSA). The structure of ZP-CT-A was characterized on the basis of 13C NMR and size exclusion chromatographic data and the results of thiolytic degradation. A mechanistic study of the effects of ZP-CT-A indicated that it suppressed the activity of β-lactamase and largely decreased the stability of the bacterial cell membrane of MRSA, as shown by a reduction in the tolerance of MRSA to low osmotic pressure and high ionic strength solutions.
- 社団法人 日本農芸化学会の論文
- 2006-06-23
著者
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吉田 隆志
Department Of Pharmacognosy College Of Pharmaceutical Sciences Matsuyama University
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波多野 力
Department Of Pharmacognosy Graduate School Of Medicine Dentistry And Pharmaceutical Sciences Okayam
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SHIOTA Sumiko
Laboratory of Pathogenic Microbiology, School of Pharmacy, Shujitsu University
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HATANO Tsutomu
Department of Pharmacognosy, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Oka
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TSUCHIYA Tomofusa
Department of Molecular Microbiology, Graduate School of Medicine, Dentistry and Pharmaceutical Scie
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YOSHIDA Takashi
Department of Pharmacognosy, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Oka
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KUSUDA Miwako
Department of Pharmacognosy, Pharmaceutical Sciences, Okayama University Graduate School of Medicine
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INADA Kazutoshi
Department of Pharmacognosy, Pharmaceutical Sciences, Okayama University Graduate School of Medicine
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OGAWA Tomo-omi
Department of Pharmacognosy, Pharmaceutical Sciences, Okayama University Graduate School of Medicine
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SHIOTA Sumiko
Department of Pathogenic Microbiology, School of Pharmacy, Shujitsu University
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Hatano Tsutomu
エジプト
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Hatano Tsutomu
Division Of Pharmaceutical Sciences Okayama University Graduate School Of Medicine Dentistry And Pha
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Hatano Tsutomu
岡山大学 医歯薬学総合研究科分子微生物学
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吉田 哲也
広島大学医学部
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Tsuchiya T
Department Of Molecular Microbiology Graduate School Of Medicine Dentistry And Pharmaceutical Scienc
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Tsuchiya Tomofusa
岡山大学 分子微生物学
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土屋 博紀
Asahi Univ. School Of Dentistry Gifu Jpn
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土屋 博紀
朝日大学歯学部口腔細菌学講座
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Hatano Tsutomu
Department Of Pharmacognosy Okayama University Graduate School Of Medicine Dentistry And Pharmaceuti
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TSUTSUMI Tomoaki
National Institute of Health Sciences
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Tsuchiya Tomofusa
Department Of Microbiology Faculty Of Pharmaceutical Sciences Okayama University
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Yoshida T
Department Of Pharmacognosy College Of Pharmaceutical Sciences Matsuyama University
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Takahashi Y
Research And Development Headquaters Hokuriku Seivaku Co. Ltd.
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Yoshida T
Hokuriku Seiyaku Co. Ltd. Fukui Jpn
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Yoshida T
Department Of Microbiology Hiroshima University School Of Medicine
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Yoshida Takashi
Department Of Agriculture Kyoto University
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Yoshida T
College Of Pharmaceutical Sciences Matsuyama University
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吉田 隆志
College Of Pharmaceutical Sciences Matsuyama University
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Yoshida Takuji
Showa Pharmaceutical University
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Shimura S
Central Laboratory Lotte Co. Ltd.
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Kusuda Miwako
Department Of Pharmacognosy Pharmaceutical Sciences Okayama University Graduate School Of Medicine D
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Shiota Sumiko
Laboratory Of Pathogenic Microbiology School Of Pharmacy Shujitsu University
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Ogawa Tomo-omi
Department Of Pharmacognosy Pharmaceutical Sciences Okayama University Graduate School Of Medicine D
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Inada Kazutoshi
Department Of Pharmacognosy Pharmaceutical Sciences Okayama University Graduate School Of Medicine D
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Tanabe Tomotaka
College Of Pharmaceutical Sciences Matsuyama University
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